952647-84-6

Upstream product

• 28437-37-8 5-C-prenylresacetophenone 
• 123-08-0 4-hydroxy-benzaldehyde 
• 1544322-43-1 (E)-1-(2,4-bis(methoxymethoxy)-5-(3-methylbut-2-en-1-yl)phenyl)-3-(4-(methoxymethoxy)phenyl)prop-2-en-1-one 
• 1544322-28-2 (E)-1-(5-iodo-2,4-bis(methoxymethoxy)phenyl)-3-(4 (methoxymethoxy)phenyl)prop-2-en-1-one 
• 6515-05-5 2',4'-bis(methoxymethoxy)acetophenone 
• 1544322-35-1 1-(5-iodo-2,4-bis(methoxymethoxy)phenyl)ethanone 
• 65490-08-6 2-hydroxy-4-(methoxymethoxy)acetophenone 
• 1314539-23-5 4,4'-bis(methoxymethoxy)-2'-prenyloxychalcone 
• 6515-21-5 4-methoxymethoxy-benzaldehyde 
• 1314539-20-2 2'-prenyloxy-4'-methoxymethoxyacetophenone 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 870-63-3 prenyl bromide 

Downstream Products

• 934247-88-8 7,4'-dimethoxymethoxy-6-(3,3-dimethylallyl)-flavanone 
• 1314539-32-6 (E)-1-(2-hydroxy-4-(methoxymethoxy)-3,5-bis(3-methylbut-2-en-1-yl)phenyl)-3-(4-(methoxymethoxy)phenyl)prop-2-en-1-one 
• 63529-05-5 (E)-1-(2,4-dihydroxy-3,5-bis(3-methylbut-2-en-1-yl)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one 
• 28448-85-3 buroussochalcone B 
• 78316-27-5 (+/-)-bavachin 

Relevant academic research and scientific papers

Microbial Transformation of Broussochalcones A and B by Aspergillus niger

Broussochalcones A (BCA, 1) and B (BCB, 2) are major bioactive constituents isolated from Broussonetia papyrifera, a polyphenol-rich plant belonging to the family Moraceae. Due to their low yields from natural sources, BCA (1) and BCB (2) were prepared sy

Synthesis and anti-cancer activity evaluation of novel prenylated and geranylated chalcone natural products and their analogs

Four natural chalcones bearing prenyl or geranyl groups, i.e., bavachalcone (1a), xanthoangelol (1b), isobavachalcone (1c), and isoxanthoangelol (1d) were synthesized by using a regio-selective iodination and the Suzuki coupling reaction as key steps. The first total synthesis of isoxanthoangelol (1d) was achieved in 36% overall yield. A series of diprenylated and digeranylated chalcone analogs were also synthesized by alkylation, regio-selective iodination, aldol condensation, Suzuki coupling and [1,3]-sigmatropic rearrangement. The structures of the 11 new derivatives were confirmed by 1H NMR, 13C NMR and HRMS. The anticancer activity of these new chalcone derivatives against human tumor cell line K562 were evaluated by MTT assay in vitro. SAR studies suggested that the 50-prenylation/geranylation of the chalcones significantly enhance their cytotoxic activity. Among them, Bavachalcone (1a) displayed the most potent cytotoxic activity against K562 with IC50 value of 2.7 mM. The morphology changes and annexin-V/PI staining studies suggested that those chalcone derivatives inhibited the proliferation of K562 cells by inducing apoptosis.

Synthesis and antibacterial activity of chalcones bearing prenyl or geranyl groups from Angelica keiskei

Chalcones bearing prenyl or geranyl groups from Angelica keiskei, such as 4-hydroxyderricin (1a), xanthoangelol (1e), xanthoangelol F (1f), xanthoangelol H (2), deoxyxanthoangelol H (3), and deoxydihydroxanthoangelol H (4) and their derivatives were synthesized. From the evaluation of antibacterial activity of the synthesized chalcones, 1a, isobavachalcone (1b), 1e, 1f, bavachalcone (5a), and broussochalcone B (5b) were found to inhibit Gram-positive bacteria.

Synthesis of four natural prenylflavonoids and their estrogen-like activities

Four prenylflavonoids, bavachin 1, isobavachin 2, 7,4′-dihydroxy-8- prenylflavone 3, and 8-prenylapigenin 4 were synthesized and recognized for possessing estrogen-like activity in MCF-7/BOS cells, as evaluated by an estrogen-screening assay. All compound