99217-72-8

Upstream product

• 1314539-20-2 2'-prenyloxy-4'-methoxymethoxyacetophenone 
• 65490-08-6 2-hydroxy-4-(methoxymethoxy)acetophenone 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 870-63-3 prenyl bromide 
• 108-46-3 recorcinol 
• 28437-37-8 5-C-prenylresacetophenone 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 1186018-77-8 2-hydroxy-3',4-di(methoxymethoxy)-5-(3,3-dimethylallyl)chalcone 
• 1186018-78-9 3-(2,4-bis(methoxymethoxy)phenyl)-1-(2-hydroxy-4-(methoxymethoxy)-5-(3-methylbut-2-en-1-yl)phenyl)prop-2-en-1-one 
• 948307-21-9 2-hydroxy-4,4’-dimethoxy methyl ether-5-isopentenyl chalcone 
• 1351279-86-1 2',4',7-trimethoxymethoxy-6-(3,3-dimethylallyl)flavanone 
• 1351279-83-8 2',4',7-trihydroxy-6-(3,3-dimethylallyl)flavone 
• 99217-68-2 broussochalcone A 
• 405261-82-7 7-methoxymethoxy-2-[4-methoxymethoxy-3-(3-methyl-but-2-enyl)-phenyl]-6-(3-methyl-but-2-enyl)-chroman-4-one 
• 78316-27-5 (+/-)-bavachin 
• 934247-88-8 7,4'-dimethoxymethoxy-6-(3,3-dimethylallyl)-flavanone 
• 405261-81-6 (E)-1-[2-Hydroxy-4-methoxymethoxy-5-(3-methyl-but-2-enyl)-phenyl]-3-[4-methoxymethoxy-3-(3-methyl-but-2-enyl)-phenyl]-propenone 
• 217442-56-3 (E)-3-(2,2-dimethyl-2H-chromen-6-yl)-1-[2-hydroxy-5-(3,3-dimethylallyl)-4-methoxymethyloxyphenyl]-2-propen-1-one 
• 99217-73-9 (E)-3-(3,4-Bis-methoxymethoxy-phenyl)-1-[2-hydroxy-4-methoxymethoxy-5-(3-methyl-but-2-enyl)-phenyl]-propenone 

Relevant academic research and scientific papers

Microbial Transformation of Broussochalcones A and B by Aspergillus niger

Broussochalcones A (BCA, 1) and B (BCB, 2) are major bioactive constituents isolated from Broussonetia papyrifera, a polyphenol-rich plant belonging to the family Moraceae. Due to their low yields from natural sources, BCA (1) and BCB (2) were prepared sy

Synthesis and evaluation of trypanocidal activity of chromane-type compounds and acetophenones

American trypanosomiasis (Chagas disease) caused by the Trypanosoma cruzi parasite, is a severe health problem in different regions of Latin America and is currently reported to be spreading to Europe, North America, Japan, and Australia, due to the migration of populations from South and Central America. At present, there is no vaccine available and chemotherapeutic options are reduced to nifurtimox and benznidazole. Therefore, the discovery of new molecules is urgently needed to initiate the drug development process. Some acetophenones and chalcones, as well as chromane-type substances, such as chromones and flavones, are natural products that have been studied as trypanocides, but the relationships between structure and activity are not yet fully understood. In this work, 26 compounds were synthesized to determine the effect of hydroxyl and isoprenyl substituents on trypanocide activity. One of the compounds showed interesting activity against a resistant strain of T. cruzi, with a half effective concentration of 18.3 μM ± 1.1 and an index of selectivity > 10.9.

Synthesis and antibacterial activity of four natural chalcones and their derivatives

Four natural chalcones bearing hydroxyisoprenyl or prenyl groups, named Paratocarpin E (2), Xanthoangelol D (3), Angusticornin A (4) and Kanzonol C (5), were prepared by employing the Claisen-Schmidt condensation as the key step. In an attempt to investigate the effect of the hydroxyisoprenyl group on biological activity, two of their derivatives were also prepared for antibacterial activity research. The synthesized compounds were investigated for their expected antibacterial activities against Gram positive bacteria (Bacillus subtilis, Staphylococcus aureus) as well as Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa). Paratocarpin E (2) was found to be the most potent against two Gram positive bacteria while the majority of the remaining compounds showed promising activity as well. However, all of the compounds were inactive against both Gram-negative bacteria.

Synthesis method and uses of natural product Bartericin A and derivative thereof

The invention discloses a synthesis method and uses of a natural product Bartericin A (I) and a derivative (II) thereof, wherein the structural formula is defined the specification, the novel isopentenyl chalcone compound is obtained, and the product has

Synthesis method and uses of natural products Stipulin (I) and Angusticornin B (II)

The invention discloses a synthesis method and uses of natural products Stipulin (I) and Angusticornin B (II), wherein the structural formula is defined in the specification. According to the presentinvention, the obtained natural products Stipulin and An

Flavonoids as vasorelaxant agents: Synthesis, biological evaluation and quantitative structure activities relationship (QSAR) studies

A series of 2-(2-diethylamino)-ethoxychalcone and 6-prenyl(or its isomers)-flavanones 10a,b and 11a-g were synthesized and evaluated for their vasorelaxant activities against rat aorta rings pretreated with 1 μM phenylephrine (PE). Several compounds showe

Synthesis of four natural prenylflavonoids and their estrogen-like activities

Four prenylflavonoids, bavachin 1, isobavachin 2, 7,4′-dihydroxy-8- prenylflavone 3, and 8-prenylapigenin 4 were synthesized and recognized for possessing estrogen-like activity in MCF-7/BOS cells, as evaluated by an estrogen-screening assay. All compound

Syntheses of (+/-)-shinflavanone and its structural analogues as potent inhibitors of bone resorption pits formation.

The first total syntheses of (+/-)-shinflavanone and its structural analogues were achieved. (+/-)-Shinflavanone, appears to be a strong inhibitor of bone resorption pits formation by osteoclast-like cell induced by 1alpha, 25-dihydroxy vitamine D3 (IC50 = 0.70 microg/mL).