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13147-57-4

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13147-57-4 Usage

Uses

Different sources of media describe the Uses of 13147-57-4 differently. You can refer to the following data:
1. Phosphoglycolic Acid is used in studies pertaining to biological and metabolic processes. It can be used in the study of human apurinic/apyrimidinic endonuclease (Ape) and its role in double strand br eak repair. It also has been seen to complex with cPEPCK (cytosolic phosphoenolpyruvate carboxykinase) during the study of its inhibition by various substrate analogues.
2. Phosphoglycolic Acid is used in studies pertaining to biological and metabolic processes. It can be used in the study of human apurinic/apyrimidinic endonuclease (Ape) and its role in double strand break repair. It also has been seen to complex with cPEPCK (cytosolic phosphoenolpyruvate carboxykinase) during the study of its inhibition by various substrate analogues.

Biochem/physiol Actions

Manifold links of photo-respiration to central metabolism, 2-phospho-glycolate content of tissues.

Check Digit Verification of cas no

The CAS Registry Mumber 13147-57-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,1,4 and 7 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 13147-57:
(7*1)+(6*3)+(5*1)+(4*4)+(3*7)+(2*5)+(1*7)=84
84 % 10 = 4
So 13147-57-4 is a valid CAS Registry Number.
InChI:InChI=1/C2H5O6P/c3-2(4)1-8-9(5,6)7/h1H2,(H,3,4)(H2,5,6,7)

13147-57-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-phosphonooxyacetic acid

1.2 Other means of identification

Product number -
Other names 2-Phosphoglycolic acid lithium salt

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:13147-57-4 SDS

13147-57-4Downstream Products

13147-57-4Relevant articles and documents

Processing the interspecies quorum-sensing signal autoinducer-2 (AI-2): Characterization of phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerization by LsrG protein

Marques, Joao C.,Lamosa, Pedro,Russell, Caitlin,Ventura, Rita,Maycock, Christopher,Semmelhack, Martin F.,Miller, Stephen T.,Xavier, Karina B.

, p. 18331 - 18343 (2011)

The molecule (S)-4,5-dihydroxy-2,3-pentanedione (DPD) is produced by many different species of bacteria and is the precursor of the signal molecule autoinducer-2 (AI-2). AI-2 mediates interspecies communication and facilitates regulation of bacterial behaviors such as biofilm formation and virulence. A variety of bacterial species have the ability to sequester and process the AI-2 present in their environment, thereby interfering with the cell-cell communication of other bacteria. This process involves the AI-2-regulated lsr operon, comprised of the Lsr transport system that facilitates uptake of the signal, a kinase that phosphorylates the signal to phospho-DPD (P-DPD), and enzymes (like LsrG) that are responsible for processing the phosphorylated signal. Because P-DPD is the intracellular inducer of the lsr operon, enzymes involved in P-DPD processing impact the levels of Lsr expression. Here we show that LsrG catalyzes isomerization of P-DPD into 3,4,4-trihydroxy-2-pentanone-5- phosphate. We present the crystal structure of LsrG, identify potential catalytic residues, and determine which of these residues affects P-DPD processing in vivo and in vitro. We also show that an lsrG deletion mutant accumulates at least 10 times more P-DPD than wild type cells. Consistent with this result, we find that the lsrG mutant has increased expression of the lsr operon and an altered profile of AI-2 accumulation and removal. Understanding of the biochemical mechanisms employed by bacteria to quench signaling of other species can be of great utility in the development of therapies to control bacterial behavior.

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