1314802-49-7Relevant academic research and scientific papers
1-Chloro-2-formyl indenes and tetralenes as antitubercular agents
Chanda, Debabrata,Saikia, Dharmendra,Kumar,Thakur, Jay Prakash,Agarwal, Jyoti,Chanotiya,Shanker, Karuna,Negi, Arvind S.
, p. 3966 - 3969 (2011)
1-Chloro-2-formyl indenes and tetralenes have been synthesized using Vilsmeier-Haack-Arnold reaction onto indanones and tetralones. Most of these analogues exhibited antitubercular activity against Mycobacterium tuberculosis H37Rv strain with MICs ranging from 30 to 500 μg/mL. Analogue 13 was further modified to some derivatives. The most active analogue 23 showing MIC at 30 μg/mL was further evaluated for acute oral toxicity in Swiss albino mice and was found to be safe up to 300 mg/kg dose.
