Bioorganic and Medicinal Chemistry Letters p. 3966 - 3969 (2011)
Update date:2022-08-03
Topics:
Chanda, Debabrata
Saikia, Dharmendra
Kumar
Thakur, Jay Prakash
Agarwal, Jyoti
Chanotiya
Shanker, Karuna
Negi, Arvind S.
1-Chloro-2-formyl indenes and tetralenes have been synthesized using Vilsmeier-Haack-Arnold reaction onto indanones and tetralones. Most of these analogues exhibited antitubercular activity against Mycobacterium tuberculosis H37Rv strain with MICs ranging from 30 to 500 μg/mL. Analogue 13 was further modified to some derivatives. The most active analogue 23 showing MIC at 30 μg/mL was further evaluated for acute oral toxicity in Swiss albino mice and was found to be safe up to 300 mg/kg dose.
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