1314867-92-9Relevant academic research and scientific papers
Characteristic structural parameters for the γ-peptide 14-helix: Importance of subunit preorganization
Guo, Li,Zhang, Weicheng,Reidenbach, Andrew G.,Giuliano, Michael W.,Guzei, Ilia A.,Spencer, Lara C.,Gellman, Samuel H.
, p. 5843 - 5846 (2011)
All wound up: Crystallographic data for a set of homologous peptides constructed from gabapentin and two to six preorganized γ-amino acid residues (see crystal structure of the longest peptide) allow derivation of characteristic parameters for the γ-peptide 14-helix and establish guidelines for characterizing 14-helical folding. The results suggest that the substitution pattern of a γ-residue has a profound effect on the propensity for 14-helical folding.
