1314905-83-3Relevant academic research and scientific papers
C2-Symmetric Chiral Bisoxazolines as Hydrogen-Bond-Acceptor Catalysts in Enantioselective Aldol Reaction of β-Carbonyl Acids with Trifluoroacetaldehyde Hemiacetals
Yang, Zhen-Yan,Zeng, Jun-Liang,Ren, Nan,Meng, Wei,Nie, Jing,Ma, Jun-An
, p. 6364 - 6367 (2016)
A simple C2-symmetric chiral bisoxazoline is demonstrated to use hydrogen bonding to catalyze an important family of aldol reactions of trifluoroacetaldehyde hemiacetals with various β-carbonyl acids. This reaction is highly enantioselective, delivering chiral nonracemic trifluoromethylated alcohols with excellent optical purity and good isolated yields. This concept of relaying chiral information via a chiral hydrogen-bond acceptor should be applicable to a vast number of organocatalytic processes.
Chiral bifunctional thiourea-catalyzed enantioselective aldol reaction of trifluoroacetaldehyde hemiacetal with aromatic ketones
Nie, Jing,Li, Xiao-Juan,Zheng, Dong-Hua,Zhang, Fa-Guang,Cui, Shumin,Ma, Jun-An
experimental part, p. 468 - 473 (2011/08/07)
In the presence of saccharide-derived bifunctional amine-thiourea catalysts, the direct aldol condensation of trifluoroacetaldehyde methyl hemiacetal with aromatic ketones proceeds to produce (R)-β-hydroxy β-trifluoroalkyl ketones in low to moderate yield
