64929-35-7

Basic information

• Product Name: 3-(4-bromophenyl)-3-oxopropanoic acid
• Synonyms: 3-(4-bromophenyl)-3-oxopropanoic acid
• CAS NO: 64929-35-7
• Molecular Weight: 243.057
• Mol File: 64929-35-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 123-125 °C
• Boiling Point: 420.8±30.0 °C(Predicted)
• Density: 1.639±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 3-(4-bromophenyl)-3-oxopropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-bromophenyl)-3-oxopropanoic acid(64929-35-7)
• EPA Substance Registry System: 3-(4-bromophenyl)-3-oxopropanoic acid(64929-35-7)

Safety Data

• Hazardous Substances Data: 64929-35-7(Hazardous Substances Data)

Usage

Physical State

White to off-white crystalline solid

Solubility

Soluble in organic solvents

Application

Intermediate in synthesis of pharmaceutical compounds and agrochemicals

Potential Uses

Building block in organic chemistry for developing new molecules with biological activity

Functional Group

Carboxylic acid

Characteristics of Carboxylic Acids

Known for acidity and reactivity in chemical reactions

Upstream product

• 333-93-7 putrescine dihydrochloride 
• 26510-95-2 ethyl 4-Bromobenzoylacetate 
• 112595-55-8 (2RS,3SR)-2,3-dibromo-3-(4-bromophenyl)propanoic acid 
• 1200-07-3 trans-4-bromocinnamic acid 
• 25294-65-9 3-(4-bromophenyl)-2-propynoic acid 
• 99-90-1 para-bromoacetophenone 
• 126629-81-0 methyl 3-(4-bromophenyl)-3-oxopropanoate 
• 14171-36-9 methyl magnesium carbonate 

Downstream Products

• 99-90-1 para-bromoacetophenone 
• 1433846-18-4 C₁₈H₁₇BrO₂ 
• 13327-66-7 2,6-bis(4-bromophenyl)-4H-pyran-4-one 
• 13541-18-9 1-(4-bromophenyl)-3,3,3-trifluoropropan-1-one 
• 1604833-43-3 (R)-1-(4-bromophenyl)-2-(2,2-dioxido-3,4-dihydrobenzo[e][1,2,3]oxathiazin-4-yl)ethanone 

Relevant articles and documents

Enantioselective decarboxylative Mannich reaction of β-keto acids withC-alkynylN-BocN,O-acetals: access to chiral β-keto propargylamines

The chiral keto-substituted propargylamines are an essential class of multifunctional compounds in the field of organic and pharmaceutical synthesis and have attracted considerable attention, but the related synthetic approaches remain limited. Therefore, a concise and efficient method for the enantioselective synthesis of β-keto propargylaminesviachiral phosphoric acid-catalyzed asymmetric Mannich reaction between β-keto acids andC-alkynylN-BocN,O-acetals as easily availableC-alkynyl imine precursors has been demonstrated here, affording a broad scope of β-ketoN-Boc-propargylamines in high yields (up to 97%) with generally high enantioselectivities (up to 97?:?3 er).

Copper-Catalysed Decarboxylative Trifluoromethylation of β-Ketoacids

An efficient method for Cu-catalyzed decarboxylative trifluoromethylation of β-ketoacids to achieve α-trifluoromethyl ketones was developed. A wide variety of synthetically useful α-trifluoromethyl ketones were obtained in modest to good yields under mild reaction conditions. The present method also exhibits good functional-group compatibility.

NITROIMIDAZOLES XI. SYNTHESES OF SUBSTITUTED (1-METHYL-5-NITRO-2-IMIDAZOLYL)PYRAZOLES

The β-diketone derivatives of nitroimidazole were synthesized from the reaction of magnesium salt of β-keto acids (2) with imidazolide (3).The β-keto acids (1) were obtained from the hydrolysis of β-keto esters (5) or the reaction of magnesium methylcarbonate with the ketone (6).The reaction of β-diketones (4) with hydrazine afforded the pyrazoles (7), which were converted to N-methylpyrazoles (8) and (9).The latters could also be obtained from the reaction of β-diketones (4) with methylhydrazine.