13150-75-9

Usage

Uses

Used in Pharmaceutical Industry:
N-(dimethyl-lambda~4~-sulfanylidene)-4-methylbenzenesulfonamide is utilized as a pharmaceutical intermediate for the synthesis of various drugs. Its unique structure allows it to serve as a key component in the development of new medicinal compounds, potentially enhancing their therapeutic properties and effectiveness.
Used in Chemical Reagent Applications:
As a chemical reagent, N-(dimethyl-lambda~4~-sulfanylidene)-4-methylbenzenesulfonamide is employed in various chemical reactions and processes. Its reactivity and stability contribute to its use in the synthesis of other organic compounds, facilitating the creation of new chemical entities with diverse applications.
Used in Organic Synthesis:
In the realm of organic synthesis, N-(dimethyl-lambda~4~-sulfanylidene)-4-methylbenzenesulfonamide acts as a building block for the construction of complex organic molecules. Its structural features enable it to be incorporated into larger molecular frameworks, providing a foundation for the development of novel organic compounds with specific properties and functions.
Used in Medicinal Chemistry Research:
Due to its potential biological activity, N-(dimethyl-lambda~4~-sulfanylidene)-4-methylbenzenesulfonamide is also used in medicinal chemistry research. It may be investigated for its interactions with biological targets, such as enzymes or receptors, to explore its potential as a lead compound in the discovery of new therapeutic agents.

Upstream product

• 75-18-3 dimethylsulfide 
• 127-65-1 chloroamine-T 
• 941-55-9 4-toluenesulfonyl azide 
• 24230-23-7 N-(4-Nitro-benzolsulfonyloxy)-toluol-4-sulfonamid 
• 4083-64-1 Tosyl isocyanate 
• 67-68-5 dimethyl sulfoxide 
• 70-55-3 toluene-4-sulfonamide 
• 37873-98-6 N-(2,4-dinitro-phenyl)-S,S-dimethyl-sulfimide 
• 40560-76-7 tosyl azide 
• 70284-20-7 N-bromo-N-potassio-p-toluenesulfonamide 
• 120263-51-6 1,7-bis(tosyl) trisulfur tetranitride 
• 207804-83-9 N-acryloyl-N-methyl-N'-p-tolylsulfonylurea 
• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 
• 937-12-2 4-tolyltrimethylstannane 

Downstream Products

• 75-18-3 dimethylsulfide 
• 70-55-3 toluene-4-sulfonamide 
• 882-33-7 diphenyldisulfane 
• 4626-23-7 3,6-Dimethyl-2-thiomethoxymethyl-phenol 
• 67869-02-7 2,3,5-Trimethyl-6-methylthiomethyl-phenol 
• 18738-36-8 2-methoxy-6-methylthiomethylphenol 
• 67869-01-6 3,5-Dimethyl-6-methylthiomethyl-phenol 
• 5485-71-2 N-(2-bromo-1-phenylethyl)-4-methylbenzenesulfonamide 
• 22236-45-9 S,S-dimethyl-N-(4-tolylsulfonyl)sulfoximine 

Relevant academic research and scientific papers

Dibenzothiophenesulfilimines: A Convenient Approach to Intermolecular Rhodium-Catalysed C?H Amidation

A sulfilimine-based Group 9 transition-metal-catalysed C?H amidation procedure is reported. Dibenzothiophene-based sulfilimines were shown to constitute a class of novel amidation reagents which enable the transfer of a wide range of N-sulfonyl and N-acyl

Copper-catalyzed imination of sulfoxides and sulfides

Sulfoximines and sulfilimines have attracted considerable interest among organic chemists. The Cu(II)-catalyzed imination of sulfoxides and sulfides using various N-fluoro benzenesulfonamides was investigated in this study. The scope of the reaction was demonstrated by using several substituted sulfides and sulfoxides. The flow strategy for the preparation of NH-sulfoximines was also examined. By trapping nitrene intermediates through triphenylphosphine, we found that the reaction was conducted through a metal-nitrene intermediate mechanism.

The Stabilized Cation Pool Method: Metal- and Oxidant-Free Benzylic C-H/Aromatic C-H Cross-Coupling

Electrochemical oxidation of toluene derivatives in the presence of a sulfilimine gave benzylaminosulfonium ions as stabilized benzyl cation pools, which reacted with subsequently added aromatic nucleophiles to give the corresponding cross-coupling produc

Highly efficient sulfimidation of 1,3-dithianes by Cu(I) complexes

A series of four Cu(I) complexes were tested for sulfimidation of 1,3-dithianes in the presence of [N-(p-tolysulfonyl)imino]phenyliodinane (PhI=NTs) as the nitrene-transfer agent. Cu(TMPhen)(PPh3)Br is an efficient catalyst with more than 90% yield of the

Heterogeneous catalytic sulfimidation using immobilized Cu(acac) 2

The heterogeneous sulfimidation of various sulfides by microencapsulated copper(II) acetylacetonate, [MC-Cu(acac)2], and Cu(acac)2 immobilized in ionic liquids using [N-(p-tolylsulfonyl)imino]phenyliodinane (PhI=NTs) as nitrene donor

Synthesis of acyclic α- and β-silyl sulfimides

Conversion of acyclic α- and β-silyl Sulfides by their treatment with sodium salts of N-chlorosulfonamides into the corresponding previously unknown sulfimides is described. The process is accompanied by a competing reaction resulting in the formation of α- or β-silyl sulfoxides. β-Silyl sulfamide (9b) undergoes thermolysis to generate trimethylvinylsilane. The Royal Society of Chemistry 2000.

Hydrogen-Transfer Polymerization of Vinyl Monomers Derived from p-Tolylsulfonyl Isocyanate and Acrylamide Derivatives

The hydrogen-transfer polymerization of N-acryloyl-N′-p-tolylsulfonylurea (1) prepared by the reaction of p-Molylsulfonyl isocyanate with acrylamide, was carried out at 80°C for 24 h in N,N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), acetonitrile (MeCN), and toluene containing N-phenyl-2-naphthylamine (1 mol%) as a radical inhibitor using t-BuOK or 1,3-diazabicyclo[5.4.0]undec-7-ene (DBU) (3 mol%) as an initiator. Polymers obtained by t-BuOK in polar solvents were composed of the hydrogen-transfer polymerization unit selectively, while those afforded by t-BuOK in less polar solvents or by DBU were composed of both the hydrogen-transfer and the vinyl polymerization units. Although Naciyloyl-N-methyl-N′-p-tolylsulfonylurea (2) prepared by the reaction of p-tolylsulfonyl isocyanate with N-methylacrylamide, gave low molecular-weight compounds (6-8) via the generation of the sulfonyl isocyanate, N-acryloyl-N′-methylN′-p-tolylsulfonylurea (3) underwent the selective hydrogen-transfer polymerization.

Unconventional Regiospecific Syntheses of Aromatic Carbonamides and Thiocarbonamides by Means of Tin-Mediated Friedel-Crafts Reactions

Friedel-Crafts reactions of stannylarenes 1 with tosyl isocyanate (TsNCO, 2) give N-tosylcarbonamides 3 via ipso substitution of the stannyl group.Thus, unconventionally substituted aromatic carbonamides can be obtained.The combination of the reaction of 1 and 2 with that of 1 and chlorosulfonyl isocyanate (14) allows one-pot syntheses of N-(arylsulfonyl)-substituted aromatic carbonamides with optional substitution patterns on both aromatic rings.The known ipso-specific substitutions of stannylarenes with 14 are extended to bi- and tricyclic arenes as well as to thiophenes 6 and 22.One stannyl group can serve as a leaving group for two aromatic systems, as shown with diaryldialkyltins 29.Also, stannylalkanes such as 27 react with 14 to afford alkylsulfonyl isocyanates and products of further reactions, such as 28.From the reactions of 1 with ethoxycarbonyl isocyanate (32), ortho- and meta-substituted aromatic thiocarbonamides 33 which are potential precursors for further syntheses, are accessible.The scope, limitations, and mechanism of these electrophilic substitutions are outlined.

Syntheses and Reactions of 1,7-Bis(tosyl) Trisulfur Tetranitride

The syntheses and reactions of the new trisulfur tetranitride 6, an oligomeric analogue of polysulfur nitride, is reported.

Chemistry of Reactive Cations Derived from Sulfur Dioxide Analogues, XIII. - Preparation and Cycloaddition Reactions of Cationic Sulfur Diimides

Two types of unsymmetrically substituted cationic sulfur diimides (1 and 2) have been synthestized.Diels-Alder reactions with 1 and 2 proceed regiospecifically in accordance with earlier hypotheses.