1315258-53-7Relevant academic research and scientific papers
Continuous-flow synthesis of 3,3-disubstituted oxindoles by a palladium-catalyzed α-arylation/alkylation sequence
Li, Pengfei,Buchwald, Stephen L.
, p. 6396 - 6400 (2011/08/21)
Facilitating chemistry: Key to the success of Pd-catalyzed α-arylation of oxindoles in continuous flow involved a biphasic system, a precatalyst, and a packed-bed microreactor. Furthermore, this reaction was integrated into a two-step continuous-flow sequence for rapid, modular, and efficient syntheses of 3,3-disubstituted oxindoles. Copyright
