131529-84-5

Upstream product

• 3350-92-3 5-phenylpent-4-ynoic acid 
• 593-51-1 methylamine hydrochloride 
• 6089-09-4 4-pentynoic acid 
• 63093-41-4 ethyl 4-pentynoate 
• 1794-48-5 1-bromo-3-phenylprop-2-yne 
• 93006-71-4 2-(3-phenylprop-2-ynyl)malonic acid diethyl ester 
• 300662-69-5 5-phenyl-4-pentynoic acid chloride 
• 74-89-5 methylamine 

Downstream Products

• 42435-96-1 5-benzoyl-N-methylpyrrolidin-2-one 
• 94532-50-0 1-methyl-2-benzylidenepyrrolidine 

Relevant academic research and scientific papers

Intramolecular PIFA-mediated alkyne amidation and carboxylation reaction

(Chemical Equation Presented) The hypervalent iodine reagent PIFA promotes the intramolecular electrophilic cyclization of easily accessible alkynylamides and alkynyl carboxylic acids, leading to the formation of pyrrolidinone and lactone skeletons, respe

New anionic cyclization of 4- and 5-alkynylamines: Synthesis of 2-Benzylidene pyrrolidines and piperidines

Treatment of 4- and 5-alkynylamines with 0.5-1.2 equiv. of butyllithium brought about a facile anionic cyclization, giving the corresponding enamine pyrrolidines and piperidines having an exo double bond in high yields. Treatment of 4-alkynamides with lit

NEW FACILE SYNTHESIS OF SUBSTITUTED 2-BENZYLIDENEPYRROLIDINES BY THE ANIONIC CYCLIZATION OF δ-ALKYNYLAMINES

Treatment of δ-alkynylamines with butyllithium or lithium aluminum hydride brought about a facile anionic cyclization, giving high yields of the corresponding enamine pyrrolidines having an exo double bound.