1315320-86-5

Upstream product

• 123-54-6 acetylacetone 
• 100-52-7 benzaldehyde 
• 106-96-7 propargyl bromide 
• 25652-50-0 5-acetyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one 
• 879343-62-1 1,1'-(4-methyl-2-oxo-6-phenyl-2,3-dihydropyrimidine-1,5(6H)-diyl)diethanone 
• 1315321-15-3 1,1'-(4-methyl-2-oxo-6-phenyl-3-(prop-2-yn-1-yl)-2,3-dihydropyrimidine-1,5(6H)-diyl)diethanone 

Relevant academic research and scientific papers

Dihydropyrimidinone/1,2,3-triazole hybrid molecules: Synthesis and anti-varicella-zoster virus (VZV) evaluation

By combining the structural features of dihydropyrimidinone and 1,2,3-triazole heterocycles, novel hybrid compounds were synthesized using a simple and convenient method. A series of novel mono and bis 1,2,3-triazole was synthesized via copper-catalyzed Huisgen azide-alkyne cycloadditions (CuAAC) under microwave irradiation. The newly synthesized compounds were evaluated for their antiviral activity against varicella-zoster virus (VZV). Compounds 6aa, 7ab, 6ba and 6da showed valuable antiviral activities, with EC50 values ranging from 3.6 to 11.3 μM against TK+ and TK- VZV and without measurable cell-growth inhibition.

Pyridopyrimidinone inhibitors of viruses

Provided herein are novel small molecule pyridomyrimidone viral inhibitor agents of Formula (I), such as 4-acetyl-2,3,7,8-tetrahydro-3-phenylpyrido[1,2-f]pyrimidin-1-one, and methods of using pharmaceutical or therapeutic compositions comprising such vira

Gold catalyzed cyclization of alkyne-tethered dihydropyrimidones

Dihydropyrimidones are an important class of biologically active heterocycles accessible from the multicomponent Biginelli condensation. Further manipulation of the dihydropyrimidone skeleton gives access to unique heterocycles. Presented herein is a Au-c