1315455-91-4Relevant academic research and scientific papers
Nucleophilic Opening of Donor-Acceptor Cyclopropanes with Indoles via Hydrogen Bond Activation with 1,1,1,3,3,3-Hexafluoroisopropanol
Irwin, Lauren C.,Renwick, Carling R.,Kerr, Michael A.
, p. 6235 - 6242 (2018)
The treatment of donor-acceptor cyclopropanes with the a strong hydrogen bond donor, HFIP, activated the cyclopropanes (via presumed hydrogen bonding) toward homo-Michael additions with indoles as the nucleophiles. This reaction proceeded without the need for high pressure or catalysis.
Nucleophilic ring opening of cyclopropane hemimalonates using internal Bronsted acid activation
Emmett, Michael R.,Kerr, Michael A.
experimental part, p. 4180 - 4183 (2011/10/02)
The reaction of cyclopropanes, geminally disubstituted with one carboalkoxy and one carbohydroxy group, undergoes ring-opening reactions with indole nucleophiles under catalyst-free, hyperbaric (13 kbar) conditions. An internal hydrogen bond is postulated
