97364-76-6

Upstream product

• 3709-32-8 6,6-dimethyl-1-phenyl-5,7-dioxaspiro[2.5]octane-4,8-dione 
• 100-52-7 benzaldehyde 
• 6626-84-2 dimethyl 2-benzylidenepropanedioate 
• 97364-76-6 1-methoxycarbonyl-2-phenylcyclopropanecarboxylic acid 

Downstream Products

• 97364-70-0 Methyl 1-methoxycarbonylamino-2-phenyl-cyclopropanecarboxylate (Z) 
• 97364-86-8 (1S,2S)-1-Isocyanato-2-phenyl-cyclopropanecarboxylic acid methyl ester 
• 3200-81-5 (1RS,2RS)-1-amino-2-phenyl-1-cyclopropanecarboxylic acid hydrochloride 
• 97364-86-8 (1S,2R)-1-Isocyanato-2-phenyl-cyclopropanecarboxylic acid methyl ester 
• 97364-76-6 methyl 2-phenylcyclopropane-1,1-dicarboxylate 

Relevant academic research and scientific papers

Tetrahydro-1,3-oxazepines via Intramolecular Amination of Cyclopropylmethyl Cation

An efficient synthesis of tetrahydro-1,3-oxazepines was developed involving the regioselective intramolecular amination of cyclopropylmethyl cation. The cation was generated by the abstraction of one imidate group in bis-imidate bearing a carbocation-stabilizing substituent. Using 1,1,2,3-tetrasubstituted cyclopropane substrates, highly diastereoselective intramolecular amination to trans-tetrahydro-1,3-oxazepines was achieved. The resulting tetrahydro-1,3-oxazepines were transformed to the homoallylamine derivatives in high yields.

GaCl3-catalyzed insertion of diazene derivatives into the cyclopropane ring

(Chemical Equation Presented) GaCl3 has been found to efficiently catalyze the formal cycloadditions of diazene derivatives 6 onto 2-arylcyclopropane-1,1-dicarboxylates 5, giving rise to the pyrazolidine derivatives 7. The insertion into the cy

SYNTHESIS OF E AND Z 1-AMINO-2-ARYL(ALKYL)-CYCLOPROPANECARBOXYLIC ACID via MELDRUM DERIVATIVES

The reaction of 5-arylidene(alkylidene)-2,2-dimethyl-1,3-dioxane-4,6-diones (1) (Meldrum's acid derivatives) with dimethylsulfoxonium methylide gave 1-aryl(alkyl)-6,6-dimethyl-4,8-dioxo-5,7-dioxaspiro octanes (2) which , on treatment with sodium meth