1315512-62-9Relevant articles and documents
Synthesis and biological evaluation of selenogefitinib for reducing bleomycin-induced pulmonary fibrosis
Bai, Yue,Chen, Lixue,Chu, Peng,Han, Xu,Li, Lei,Li, Yanxia,Ma, Xiaodong,Qi, Yan,Sun, Huijun,Wang, Changyuan,Zhang, Baojing,Zhang, Yunhao
, (2021)
Selenium has demonstrated effectiveness in the reduction of oxidative stress and inflammation in vitro and in vivo, both of which are key indicators of the pathogenesis of pulmonary fibrosis. Gefitinib, an FDA-approved EGFR inhibitor, effectively reverses
Novel 4-arylaminoquinazoline derivatives with (E)-propen-1-yl moiety as potent EGFR inhibitors with enhanced antiproliferative activities against tumor cells
Chen, Li,Zhang, Yaling,Liu, Juan,Wang, Weijia,Li, Xiabing,Zhao, Lijun,Wang, Wei,Li, Baolin
, p. 689 - 697 (2017/07/17)
A series of novel 4-anilinoquinazoline derivatives with (E)-propen-1-yl moiety were designed, synthesized and evaluated for biological activities in vitro. Most compounds exhibited highly antiproliferative activities against all tested tumor cell lines in