131558-76-4

Upstream product

• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 108-86-1 bromobenzene 
• 93790-54-6 [2-(4-iodophenoxy)ethyl]dimethylamine 
• 536-74-3 phenylacetylene 
• 2474-07-9 [2-(4-bromophenoxy)ethyl]dimethylamine 

Downstream Products

• 921212-39-7 C₂₆H₂₇NO₃ 
• 604010-57-3 (2E)-3-{4-[2-(dimethylamino)ethoxy]phenyl}-2,3-diphenylprop-2-en-1-ol 
• 604010-59-5 (2E)-3-{4-[2-(dimethylamino)ethoxy]phenyl}-2,3-diphenylprop-2-en-1-al 
• 604010-60-8 (Z)-2-(4-(1,2-diphenylbuta-1,3-dien-1-yl)phenoxy)-N,N-dimethylethanamine 
• 10540-29-1 tamoxifen 

Relevant academic research and scientific papers

Effective synthesis of tamoxifen using nickel-catalyzed arylative carboxylation

Tamoxifen was synthesized using a nickel-catalyzed arylative carboxylation developed by our group. The key compound, tetrasubstituted alkene, was synthesized from disubstituted alkyne using a catalytic amount of Ni(0) and DBU in the presence of Ph2Zn under an atmosphere of carbon dioxide. The reaction proceeded smoothly in a regio- and stereoselective manner, and the resultant tetrasubstituted alkene was converted into tamoxifen. Georg Thieme Verlag Stuttgart.

Synthesis of mono- and diarylacetylenes

Arylacetylenes have been synthesized by C-C coupling of lithium acetylide with aryl bromide in the presence of a palladium(0) catalyst.