604010-60-8

Usage

Uses

Used in Pharmaceutical Industry:
Fluoxetine is used as an antidepressant for the treatment of depression, obsessive-compulsive disorder, panic disorder, and bulimia. Its mechanism of action involves the selective inhibition of serotonin reuptake, leading to an increase in the availability of serotonin in the synaptic cleft and consequently improving mood and other related symptoms.
Used in Treatment of Premenstrual Dysphoric Disorder:
Fluoxetine is also utilized in the treatment of premenstrual dysphoric disorder (PMDD), a severe form of premenstrual syndrome. It helps alleviate the emotional and physical symptoms associated with PMDD by modulating serotonin levels.
Used in Capsule or Liquid Form:
Fluoxetine is available in the form of a capsule or liquid, providing flexibility in administration and catering to the needs of different patients. It is typically taken once daily, either in the morning or evening, and may require several weeks to show noticeable improvements.
Side Effects and Tolerability:
While fluoxetine may cause side effects such as nausea, diarrhea, insomnia, and sexual problems, it is generally well-tolerated by patients. The benefits of the medication often outweigh the potential side effects, making it a popular choice for the treatment of various mental health conditions.

Upstream product

• 1779-49-3 Methyltriphenylphosphonium bromide 
• 604010-59-5 (2E)-3-{4-[2-(dimethylamino)ethoxy]phenyl}-2,3-diphenylprop-2-en-1-al 
• 604010-56-2 3-{4-[2-(dimethylamino)ethoxy]phenyl}prop-2-yn-1-ol 
• 93790-54-6 [2-(4-iodophenoxy)ethyl]dimethylamine 
• 540-38-5 p-Iodophenol 
• 604010-57-3 (2E)-3-{4-[2-(dimethylamino)ethoxy]phenyl}-2,3-diphenylprop-2-en-1-ol 
• 131558-76-4 Dimethyl-[2-(4-phenylethynyl-phenoxy)-ethyl]-amine 
• 921212-39-7 C₂₆H₂₇NO₃ 

Downstream Products

• 10540-29-1 tamoxifen 

Relevant academic research and scientific papers

Oxidative heck arylation for the stereoselective synthesis of tetrasubstituted olefins using nitroxides as oxidants

One, two, and three! Nitroxides and dioxygen serve as oxidants in highly stereoselective oxidative Pd-catalyzed Heck arylations in which aryl boronic acids are used to synthesize triarylalkyl-substituted olefins. The reactions occur under very mild conditions at room temperature. As an example, the threefold sequential arylation of methyl acrylate is the crucial step in the stereoselective synthesis of Z-Tamoxifen.

Effective synthesis of tamoxifen using nickel-catalyzed arylative carboxylation

Tamoxifen was synthesized using a nickel-catalyzed arylative carboxylation developed by our group. The key compound, tetrasubstituted alkene, was synthesized from disubstituted alkyne using a catalytic amount of Ni(0) and DBU in the presence of Ph2Zn under an atmosphere of carbon dioxide. The reaction proceeded smoothly in a regio- and stereoselective manner, and the resultant tetrasubstituted alkene was converted into tamoxifen. Georg Thieme Verlag Stuttgart.

(Z)-tamoxifen and tetrasubstituted alkenes and dienes via a regio- and stereospecific three-component magnesium carbometalation palladium(O) cross-coupling strategy

(Matrix presented) The synthesis of various tetrasubstituted alkenes and dienes in a regio- and stereocontrolled manner is described. This three-component coupling strategy involves the addition of Grignard reagents to propargyl alcohols followed by palladium(O)-mediated cross-coupling with aryl or vinyl halides. This protocol has been applied to the synthesis of (Z)-Tamoxifen and related mimics.