1352410-70-8

Basic information

• Product Name: rac-6-(2-(1-(tert-butyldimethylsilyl)-1H-indol-4-yl)propan-2-yl)-3-methyl-2-((trimethylsilyl)oxy)-3-vinylcyclohexanone
• Synonyms: rac-6-(2-(1-(tert-butyldimethylsilyl)-1H-indol-4-yl)propan-2-yl)-3-methyl-2-((trimethylsilyl)oxy)-3-vinylcyclohexanone
• CAS NO: 1352410-70-8
• Molecular Weight: 497.869
• Mol File: 1352410-70-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: rac-6-(2-(1-(tert-butyldimethylsilyl)-1H-indol-4-yl)propan-2-yl)-3-methyl-2-((trimethylsilyl)oxy)-3-vinylcyclohexanone(CAS DataBase Reference)
• NIST Chemistry Reference: rac-6-(2-(1-(tert-butyldimethylsilyl)-1H-indol-4-yl)propan-2-yl)-3-methyl-2-((trimethylsilyl)oxy)-3-vinylcyclohexanone(1352410-70-8)
• EPA Substance Registry System: rac-6-(2-(1-(tert-butyldimethylsilyl)-1H-indol-4-yl)propan-2-yl)-3-methyl-2-((trimethylsilyl)oxy)-3-vinylcyclohexanone(1352410-70-8)

Safety Data

• Hazardous Substances Data: 1352410-70-8(Hazardous Substances Data)

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 193694-04-1 N-TBS-4-bromoindole 
• 1352410-68-4 C₁₅H₃₀O₂Si₂ 
• 1352410-69-5 4-(2-hydroxy-2-propyl)-N-TBS-indole 
• 52488-36-5 4-bromo-1H-indole 

Downstream Products

• 101968-75-6 (+/-)-hapalindole U 
• 131572-81-1 rac-(R)-6,6,9-trimethyl-2-tosyl-9-vinyl-6,7,8,9-tetrahydronaphtho[1,2,3-cd]indol-10(2H)-one 

Relevant articles and documents

Total synthesis of hapalindoles J and U

The total synthesis of d,l-hapalindoles J and U has been accomplished. Hapalindole J was prepared in 11% overall yield over 11 synthetic steps and hapalindole U was prepared in 25% overall yield over 13 synthetic steps from commercially available materials. The route employs a novel silyl ether-based strategy for accessing the 6:5:6:6 ring system of the hapalindoles rapidly and in good yields.