13159-82-5

Upstream product

• 3526-45-2 2-((phenylamino)methyl)phenol 
• 89-95-2 2-methyl-benzyl alcohol 
• 540-37-4 p-aminoiodobenzene 
• 3489-07-4 N-Salicyliden-p-iodanilin 

Downstream Products

• 622400-20-8 N-(2-hydroxybenzyl)-N-(4-iodophenyl)-3-phenylpropynamide 
• 716316-97-1 2-bromo-N-(2-hydroxybenzyl)-N-(4-iodophenyl)-3-phenylpropionamide 
• 1258930-27-6 2-chloro-N-(2-hydroxybenzyl)-N-(4-iodophenyl)acetamide 
• 716317-04-3 4-(2-benzyl-3-oxo-2,3,4,5-tetrahydrobenz[f][1,4]oxazepin-4-yl)-N'-hydroxybenzamidine 
• 716317-07-6 4-[{2-(Z)-benzylidene-3-oxo-2,3,4,5-tetrahydrobenz[f][1,4]oxazepin-4-yl}]benzonitrile 
• 716317-01-0 2-benzyl-4-(4-iodophenyl)-2,3,4,5-tetrahydrobenz[f][1,4]oxazepin-3-one 
• 716317-02-1 4-(2-benzyl-3-oxo-2,3,4,5-tetrahydrobenz[f][1,4]oxazepin-4-yl)benzonitrile 

Relevant academic research and scientific papers

Synthesis and structure-antibacterial activity relationship studies of 4-substituted phenyl-4,5-dihydrobenzo[f][1,4]oxazepin-3(2H)-thiones

The synthesis and characterization of a series of 4-substituted phenyl-4,5-dihydrobenzo[f][1,4]oxazepin- 3(2H)-thiones were presented. Preliminary in vitro antimicrobial activity of the compounds was assessed against a panel of microorganisms including S.

Synthesis of substituted 1,4-benzoxazepin-3-one derivatives

A synthesis of substituted 1,4-benzoxazepin-3-one is described starting from salicylaldehyde, aniline and chloroacetyl chloride. Use of 2-bromo-3-phenylpropionyl chloride gave access to 2-benzyl-1,4-benzoxazepin-3-one; an addition/elimination sequence afforded the corresponding benzylidene derivative which structure has been confirmed by an X-Ray analysis. Biphenyl substituents were also introduced in position -4 of this scaffold.

Synthesis of 5-(4-aryl)-2-phenyl-5,6-dihydrobenzo[bl[1,5]oxazocin-4-ones

Cyclization of N-aryl-N-(2-hydroxybenzyl)-3-phenylpropynamide in basic medium under the influence of a catalytic amount of Pd(0) afforded the eight-membered framework 5-(4-aryl)-2-phenyl-5,6-dihydrobenzo[b][1,5]-oxazocin-4-ones.

On the formation of aromatic secondary amine-iodine complexes

The aromatic secondary amines (SA) form 1:1 charge-transfer (CT) complexes with iodine.The formation constants lie in the range Kc ca. 60-180, depending on the N-phenyl substituents.The changes in the visible spectra with time indicate the partial iodination of the aniline ring in a first-order reaction.