3526-45-2Relevant articles and documents
A Facile Reduction Procedure for N,N′-bis[5-Substituted Salicylidene]-m/p-phenylenediamines with Sodium Borohydride-Silica Gel System
Sridharan,Muthusubramanian,Sivasubramanian
, p. 1087 - 1096 (2004)
An easy approach involving sodium borohydride/silica gel system offers a fast method of reduction for N,N′-bis[5-substituted salicylidene] m/p-phenylenediamines to the corresponding amines with excellent yield. The observed formation of boron chelates in
Monitoring of reduction reaction of 2-((phenylimino)methyl)phenol compound with sodium borohydride in solution by infrared spectroscopy
Turhan, Onur,Ya?ar, Hatice
, (2020)
In this study, an imine compound 2-((phenylimino)methyl)phenol was synthesized by the reaction of salicylaldehyde and aniline for in situ monitoring of reduction with sodium borohydride. The reduction of C = N double bond to C–N in solution was continuous
Sulfated polyborate: A dual catalyst for the reductive amination of aldehydes and ketones by NaBH4
Ganwir, Prerna,Chaturbhuj, Ganesh
, (2021/05/19)
An efficient, quick, and environment-friendly one-pot reductive amination of aldehydes or ketones was developed. In ethanol at 70 °C, a imination catalyzed by sulfated polyborate and further reduced by sodium borohydride yields various amines. The present method has many significant benefits, including a shorter reaction time, excellent yields, and a hassle-free, straightforward experimental process. The reaction has a wide range of applications due to its flexibility, including secondary amine for reductive amination.
Chiral N-heterocyclic carbene-iridium complexes for asymmetric reduction of prochiral ketimines
Kathuria, Lakshay,Samuelson, Ashoka G.
supporting information, (2020/12/28)
Enantioselective reduction of imines to the corresponding chiral secondary amines has been studied using a series of chiral half-sandwich iridium complexes. Chiral N-heterocyclic carbene (NHC) ligands in these complexes were synthesized from readily available, naturally occurring amino acids. Inexpensive phenylsilane was used as a convenient hydrogen donor. Under the optimized conditions, Ir-NHC complexes could reduce ketimines in good yields, albeit with moderate enantiomeric excess (ee). The phenylglycine derived chiral NHC was shown to give the best Ir catalyst and it also gave the maximum ee compared to catalysts prepared from other NHCs in this series. The opposite enantiomer of the reduction product was always obtained while using the Ir complex bearing a valine based NHC. The yields were consistently high with a variety of imine substrates having different steric and electronic demands.
