131605-42-0Relevant articles and documents
Niraparib important intermediate and enzymatic synthesis method thereof
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, (2020/05/08)
The invention discloses a niraparib important intermediate and an enzymatic synthesis method thereof. The synthesis method is as follows: taking 2-(4-nitrophenyl) dimethyl malonate as a raw material;dissolving the raw material in methanol, and adding sodi
Enzyme catalyzed monohydrolysis of 2-aryl-1 3-propanediol diacetates. A study of structural effects of the aryl moiety on the enantioselectivity
Guanti, Giuseppe,Narisano, Enrica,Podgorski, Tadeusz,Thea, Sergio,Williams, Andrew
, p. 7081 - 7092 (2007/10/02)
PPL catalyzed monohydrolysis of 2-aryl substituted 13-propanediol diacetates afforded the corresponding monoacetates in acceptable to fair chemical and optical yields. Electronic effects in the aromatic ring were examined. Elaboration of some 2-arylpropanediol monoacetates to optically active 2-arylpropanols and propanoic acids was performed.