13161-80-3Relevant articles and documents
1-Oxo-2-hydroxy-1,2-dihydroacronycine: A useful synthon in the acronycine series for the introduction of amino substituents at 6-position and for the conversion into isopropylfuroacridones
Magiatis,Mitaku,Skaltsounis,Tillequin
, p. 1304 - 1307 (2001)
Thermic aromatic nucleophilic displacement of the methoxy group at C-6 of (±)-1-oxo-2-hydroxy-1,2-dihydroacronycine (2) by an amine is a reaction that gives a facile entry to acronycine derivatives bearing an amino substituent at this position. The introduction of the amino substituents was confirmed with a long-range 1H-15N correlation NMR spectrum at natural abundance. Under basic conditions, compound 2 can also be rearranged to the corresponding isopropylfuroacridone 12, in 80% yield.
Synthesis of acronycine.
Beck,Kwok,Booher,Brown,Patterson,Pranc,Rockey,Pohland
, p. 4706 - 4710 (2007/10/05)
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