1316645-29-0

Upstream product

• 100-52-7 benzaldehyde 
• 95601-03-9 [1-(diethoxyphosphoryl)-2-phenyl-vinyl]-phosphonic acid diethyl ester 
• 66646-88-6 methyl 2-(benzylideneamino)acetate 
• 1660-94-2 Tetraethyl methylenediphosphonate 

Downstream Products

• 1316645-42-7 (2S,3R)-methyl 2-benzamido-4,4-bis(diethoxyphosphoryl)-4-hydroxy-3-phenylbutanoate 
• 1316645-40-5 (2S,3R)-methyl 2-benzamido-4-chloro-4,4-bis(diethoxyphosphoryl)-3-phenylbutanoate 
• 1316645-38-1 (2S,3R)-methyl 2-benzamido-4,4-bis(diethoxyphosphoryl)-4-fluoro-3-phenylbutanoate 
• 1316645-36-9 (2S,3R )-methyl 2-benzamido-4,4-bis(diethoxyphosphoryl)-3-phenylbutanoate 
• 1316645-34-7 (2S,3R)-methyl 4,4-bis(dimethoxyphosphoryl)-2-(dimethylamino)-3-phenylbutanoate 
• 1316645-32-5 (2R,3S)-3-amino-4-methoxy-4-oxo-2-phenylbutane-1,1-diyldiphosphonic acid 
• 1315613-53-6 (2S,3R)-methyl 2-amino-4,4-bis(diethoxyphosphoryl)-3-phenylbutanoate 

Relevant academic research and scientific papers

A Facile Cu(I)/TF-BiphamPhos-catalyzed asymmetric approach to unnatural α-amino acid derivatives containing gem-bisphosphonates

A novel catalytic asymmetric Michael addition of azomethine ylide with β-substituted alkylidene bisphosphates was realized in the presence of a chiral copper(I)/TF-BiphamPhos complex. The present system provides a unique and facile access to enantioenriched unnatural α-amino acid derivatives containing gem-bisphosphonates (gem-BPs) in high yields with excellent diastereoselectivities and enantioselectivities. Subsequent transformations lead to the expedient preparation of biologically active unnatural α-amino acid derivatives containing BPs and bisphosphonic acids without loss of diastereo- and enantiomeric excess.