4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylicacid, 5,6-dihydro-8-hydroxy-5-methyl-6-oxo-, ethyl ester

Base Information

Chemical Name:4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylicacid, 5,6-dihydro-8-hydroxy-5-methyl-6-oxo-, ethyl ester
CAS No.:131666-45-0
Molecular Formula:C₁₅H₁₅N₃O₄
Molecular Weight:301.302
Hs Code.:
Mol file:131666-45-0.mol

Synonyms:Ro 40-1518

Suppliers and Price of 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylicacid, 5,6-dihydro-8-hydroxy-5-methyl-6-oxo-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Defluoro8-HydroxyFlumazenil(Impurity)
2.5mg
$ 160.00

Sigma-Aldrich
Flumazenil impurity B European Pharmacopoeia (EP) Reference Standard
y0000335
$ 190.00

Sigma-Aldrich
Flumazenil impurity B
20mg
$ 1490.00

AK Scientific
Ethyl8-hydroxy-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
5mg
$ 329.00

Total 7 raw suppliers

Chemical Property of 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylicacid, 5,6-dihydro-8-hydroxy-5-methyl-6-oxo-, ethyl ester

Chemical Property:

Boiling Point:588.6±50.0 °C(Predicted)
PKA:8.54±0.20(Predicted)
PSA：84.66000
Density:1.42±0.1 g/cm3(Predicted)
LogP:1.27810

Purity/Quality:

98% ^*data from raw suppliers

Defluoro8-HydroxyFlumazenil(Impurity) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Defluoro 8-hydroxy Flumazenil is an impurity of Flumazenil (F500450), a benzodiazepine antagonist that can prevent or abolish (at the receptor level) the effects of a benzodiazepine.

Technology Process of 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylicacid, 5,6-dihydro-8-hydroxy-5-methyl-6-oxo-, ethyl ester

There total 6 articles about 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylicacid, 5,6-dihydro-8-hydroxy-5-methyl-6-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 78756-37-3
ethyl 8-bromo-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate

: 131666-45-0
8-hydroxy-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid ethyl ester

Guidance literature:: With [(2-di-tert-butylphosphino-3-methoxy-6-methyl-2,4,6-triisopropyl-1,1-biphenyl)-2-(2-aminobiphenyl)]palladium(II) methanesulfonate; caesium carbonate; Benzaldoxime; In N,N-dimethyl-formamide; at 80 ℃; for 18h; Inert atmosphere; Glovebox; Sealed tube;
DOI:10.1002/anie.201700244

Reference yield: 4.0%

: 64-17-5
ethanol

: ethyl 8-methoxy-5,6-dihydro-5-methyl-6-oxo-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylate

: 131666-45-0
8-hydroxy-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid ethyl ester

Guidance literature:: ethyl 8-methoxy-5,6-dihydro-5-methyl-6-oxo-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylate; With boron tribromide; In dichloromethane; at -70 ℃;

ethanol; In dichloromethane; at 20 ℃; Cooling;

Reference yield:

: 2999-46-4
Ethyl isocyanoacetate

: 131666-45-0
8-hydroxy-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran; mineral oil / Inert atmosphere

1.2: Cooling; Inert atmosphere

1.3: 18 h / 20 °C / Inert atmosphere

2.1: boron tribromide / dichloromethane / -70 °C

2.2: 20 °C / Cooling

With boron tribromide; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;