131682-41-2

Basic information

• Product Name: 1-[(2R,4R,5S)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4-dione
• Synonyms: 1-[(2R,4R,5S)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4-dione
• CAS NO: 131682-41-2
• Molecular Weight: 242.232
• Mol File: 131682-41-2.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: 1-[(2R,4R,5S)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(2R,4R,5S)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4-dione(131682-41-2)
• EPA Substance Registry System: 1-[(2R,4R,5S)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4-dione(131682-41-2)

Safety Data

• Hazardous Substances Data: 131682-41-2(Hazardous Substances Data)

Usage

Composition

Pyrimidine ring with a methyl group at carbon 5
Tetrahydrofuran ring with a hydroxymethyl group at carbon 5

Role in DNA

One of the four nucleobases that make up DNA

Genetic code

Plays a crucial role by pairing with adenine through hydrogen bonding

Hydrogen bond interactions

Hydroxyl and carbonyl groups allow it to participate in hydrogen bond interactions
Forms base pairs that hold together the two complementary strands of DNA

Function

Essential component of genetic material

Involvement

Involved in the storage and transmission of genetic information in all living organisms

Upstream product

• 65-71-4 thymin 
• 793716-98-0 3',5'-di-O-levulinoyl-β-L-thymidine 
• 271248-28-3 3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)-L-thymidine 
• 237060-98-9 2',3',5'-tri-O-benzoyl-5-methyl-L-uridine 
• 50571-26-1 5'-DMT-thymidine-3'-H-phosphonate 
• 50-89-5 thymidine 
• 1062488-85-0 C₂₆H₂₆N₂O₇ 
• 132969-97-2 1-(2-O-Acetyl-3,5-di-O-benzoyl-α-L-arabinofuranosyl)thymine 
• 132969-98-3 C₂₄H₂₂N₂O₈ 
• 133008-03-4 1,2-Di-O-acetyl-3,5-di-O-benzoyl-L-arabinofuranose 
• 16033-24-2 1-<α-L-Arabinofuranosyl>thymine 
• 3795-68-4 methyl α-L-arabinofuranoside 
• 189074-35-9 1-O-Acetyl-2,3,5-tri-O-benzoyl-α/β-L-arabinofuranoside 
• 137147-00-3 1-<2'-O-Phenoxythiocarbonyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-α-L-arabinofuranosyl>thymine 

Downstream Products

• 1356470-38-6 5-((5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)methyl)-2'-deoxy-β-L-uridine 
• 1356470-37-5 3',5'-di-O-acetyl-5-((5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)methyl)-2'-deoxy-β-L-uridine 
• 132979-39-6 1-(3-azido-2,3-dideoxy-β-L-erythro-pentofuranosyl)thymine 
• 1333996-11-4 C₂₁H₂₇N₆O₈P 
• 1333995-93-9 C₂₁H₂₇N₁₀O₆P 
• 1333995-78-0 C₂₁H₂₅ClN₉O₆P 
• 1333995-50-8 C₂₁H₂₆N₉O₆P 
• 1333995-40-6 C₂₁H₂₄ClN₈O₆P 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 52417-09-1 3'-O-(4,4'-dimethoxytriphenylmethyl)-5'-O-fluorenylmethoxycarbonylthymidine 
• 137147-01-4 3'-O-Methylsulfonyl-5'-O-triphenylmethyl-α-L-thymidine 
• 137147-02-5 1-(3'-Azido-2',3'-dideoxy-5'-O-triphenylmethyl-α-L-threo-pentofuranosyl)thymine 
• 132970-02-6 1-(3'-Azido-2',3'-dideoxy-α-L-threo-pentofuranosyl)thymine 
• 207128-19-6 1-((2S,4R,5S)-4-Fluoro-5-trityloxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 

Relevant articles and documents

Meteorite-catalyzed intermoleculartrans-glycosylation produces nucleosides under proton beam irradiation

Di-glycosylated adenines act as glycosyl donors in the intermoleculartrans-glycosylation of pyrimidine nucleobases under proton beam irradiation conditions. Formamide and chondrite meteorite NWA 1465 increased the yield and the selectivity of the reaction

MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF

The present disclosure provides oligomeric compounds comprising a modified oligonucleotide having at least one stereo-non-standard nucleoside.

Method for preparing telbivudine

The invention relates to a method for preparing telbivudine. The reaction mechanism is as shown in the specification specifically. Compared with a method of the prior art, the method provided by the invention has the advantages that firstly, all raw materials are low in cost and can be easily obtained from the market; secondly, reaction of different steps is normal reaction, and the reaction steps are simple and easy to implement; and thirdly, production requirements can be met by using normal preparation equipment, the production is easy to control, and industrial production can be achieved.