1316852-08-0

Basic information

• Product Name: 14-phenyl-1,2-dihydroquinolino[2',3':3,4]-pyrrolo[2,1-b]quinazoline-5,8(13H)-dione
• Synonyms: 14-phenyl-1,2-dihydroquinolino[2',3':3,4]-pyrrolo[2,1-b]quinazoline-5,8(13H)-dione
• CAS NO: 1316852-08-0
• Molecular Weight: 379.418
• Mol File: 1316852-08-0.mol

Chemical Properties

• CAS DataBase Reference: 14-phenyl-1,2-dihydroquinolino[2',3':3,4]-pyrrolo[2,1-b]quinazoline-5,8(13H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 14-phenyl-1,2-dihydroquinolino[2',3':3,4]-pyrrolo[2,1-b]quinazoline-5,8(13H)-dione(1316852-08-0)
• EPA Substance Registry System: 14-phenyl-1,2-dihydroquinolino[2',3':3,4]-pyrrolo[2,1-b]quinazoline-5,8(13H)-dione(1316852-08-0)

Safety Data

• Hazardous Substances Data: 1316852-08-0(Hazardous Substances Data)

Upstream product

• 57623-73-1 2-(phenylamino)benzoyl chloride 
• 91-40-7 2-(phenylamino)benzoic acid 
• 1316852-06-8 14-(3-(trifluoromethyl)phenyl)-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one 

Downstream Products

• 1316852-13-7 8-chloro-14-phenyl-1,2-dihydroquinolino-[2',3':3,4]pyrrolo[2,1-b]quinazolin-5-one 
• 1316852-15-9 8-morpholino-14-phenyl-1,2-dihydroquinol-ino[2',3':3,4]pyrrolo[2,1-b]quinazolin-5-one 
• 1316852-11-5 8-acetyloxy-14-phenyl-1,2-dihydroquinolino-[2',3':3,4]pyrrolo[2,1-b]quinazolin-5-one 

Relevant articles and documents

Intramolecular N-aza-amidoalkylation in association with Witkop-Winterfeldt oxidation as the key step to synthesize Luotonin-A analogues

An expedient four-step approach for the synthesis of a short library of original analogues of the Topo-I Luotonin-A inhibitor, substituted at their C8- and N15-positions, was investigated. This consists of Rutaecarpines formation, their Witkop-Winterfeldt oxidation followed ultimately with functional adjustment of the pyrroloquinolone intermediates. In the first step of these investigations, Rutaecarpines including the Topo-I poison Evodiamine were obtained via the new tandem N-acylation/aza-amidoalkylation using a nitrogen atom as an internal nucleophile with or without association with a decarboxylation.