13170-19-9Relevant academic research and scientific papers
Method for Producing Acyloxysilanes, Acyloxysilanes Obtained Thereby, and Use of Same
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Paragraph 0131, (2018/03/25)
An object of the invention is to provide a method for efficiently producing an acyloxysilane which is useful as a functional chemical, an acyloxysilane obtained thereby, and the use thereof. The present invention provides: a method for producing an acyloxysilane, including a reaction step of reacting an alkoxysilane with a carboxylic anhydride in the presence of a catalyst, wherein the alkoxysilane is a specified alkoxysilane represented by General Formula (I), the carboxylic anhydride is a specified carboxylic acid represented by General Formula (IIA) or (IIB), the catalyst is an acid catalyst, and an acyloxysilane obtained in the reaction step is a specified acyloxysilane represented by General Formula (IIIA) or (IIIB); and the use of the acyloxysilane as a surface treatment agent or the like.
Catalytic enantioselective Mannich-type reactions of ketoimines
Suto, Yutaka,Kanai, Motomu,Shibasaki, Masakatsu
, p. 500 - 501 (2007/10/03)
The first example of catalytic enantioselective Mannich-type reactions of simple ketoimines is described. The optimized conditions for aromatic ketoimines include the use of CuOAc-DTBM-SEGPHOS as the catalyst (10 mol %) and (EtO)2Si(OAc)2 as the trapping reagent (1 equiv) of the intermediate copper amide (generated via the addition of a copper enolate to the imine). The trapping reagent significantly facilitated the catalyst turnover. Excellent enantioselectivity was produced from a range of aromatic ketoimines, including heteroaromatic and ethyl-substituted ketoimines. The optimized conditions for aliphatic ketoimines include the use of CuOAc-4-tBu-cyclohexyl-DuPHOS as the catalyst and (EtO)3SiF as the trapping reagent. When aliphatic substrates were used, the enantioselectivity was in the 77-81% ee range. The products were converted to β,β-disubstituted amino acids, which are a very important class of chiral building blocks for natural product synthesis, pharmaceuticals, and conformationally regulated artificial proteins. Copyright
