131747-32-5

Usage

Uses

Used in Organic Synthesis:
(4-nitropyridin-2-yl)methyl acetate is used as a building block in the production of pharmaceuticals, agrochemicals, and specialty chemicals due to its strong electrophilic nature and ability to participate in various organic reactions.
Used in Pharmaceutical Industry:
(4-nitropyridin-2-yl)methyl acetate is used as a key intermediate in the synthesis of complex organic molecules for drug development, leveraging its reactivity in forming carbon-carbon and carbon-nitrogen bonds.
Used in Agrochemical Industry:
(4-nitropyridin-2-yl)methyl acetate is employed as a precursor in the development of agrochemicals, contributing to the creation of effective and stable compounds for agricultural applications.
Used in Specialty Chemicals Industry:
(4-nitropyridin-2-yl)methyl acetate is utilized as a versatile intermediate in the synthesis of specialty chemicals, taking advantage of its high stability and low reactivity towards common reagents.
Used in Organic Reactions:
(4-nitropyridin-2-yl)methyl acetate is used as a reactant in various organic reactions, such as nitro reduction, nucleophilic aromatic substitution, and transition metal-catalyzed coupling reactions, due to its strong electrophilic properties and reactivity.

Upstream product

• 5470-66-6 2-methyl-4-nitropyridine N-oxide 
• 108-24-7 acetic anhydride 
• 931-19-1 2-methylpyridine N-oxide 

Downstream Products

• 108338-19-8 4-nitro-2-pyridinecarboxaldehyde 
• 108337-77-5 2-(N-Benzyl-N-methylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(4-nitro-2-pyridyl)-3,5-pyridinedicarboxylate 

Relevant academic research and scientific papers

Chiral amine-imine ligands based on trans-2,5-disubstituted pyrrolidines and their application in the palladium-catalyzed allylic alkylation

A series of amine-imine bidentate ligands based on a trans-2,5-disubstituted pyrrolidine and pyridine moieties have been prepared. The use of these ligands in the palladium-catalyzed allylic alkylation reaction of rac-(E)-1,3-diphenylprop-2-enyl acetate is reported. The results suggest that these ligands are good catalyst precursors for the reaction. Electronic modification on the pyridine ring of the ligands does not have a significant effect on the enantioselectivity of the reaction but does on the reaction rate, while structural modification on either the pyridine or the pyrrolidine moiety affords dramatic changes on the outcome of the stereochemistry. Evidence from various studies suggested that during the palladium-catalyzed allylic alkylation reaction, nucleophilic attack onto the 1,3-diphenylallyl moiety in the transition state occurs mainly trans to the pyridine ring of the less stable conformation of the palladium complexes.

PHTHALAZINONE DERIVATIVES

A compound of the formula (I): wherein: A and B together represent an optionally substituted, fused aromatic ring; D is selected from: (i) ?where Y1 is selected from CH and N, Y2 is selected from CH and N, Y3 is selected f

Method for labelling phosphorylated peptides, complex compounds used in the methods, process for producing the same, and their intermediates

Provided are a method for easily detecting phosphorylated peptides, namely, proteins, in samples derived from living organisms or the like, a method for selectively adsorbing the phosphorylated peptides, and compounds that are highly coordinated to the phosphorylated peptides and usable in the methods. The complex compound is represented by the formula: wherein X is a linker moiety, and Y is a labeling group. The compound (I) is highly coordinated to a phosphorylated peptide. and has a labeling group. Accordingly, with use of the compound (I), the phosphorylated peptide can be easily identified.

Superoxide dismutase activity of iron(II)TPEN complex and its derivatives

Superoxide is involved in the pathogenesis of various diseases, such as inflammation, ischemia-reperfusion injury and carcinogenesis. Superoxide dismutases (SODs) catalyze the disproportionation reaction of superoxide to produce oxygen and hydrogen peroxide, and can protect living cells against the toxicity of free radicals derived from oxygen. Thus, SODs and their functional mimics have potential value as pharmaceuticals. We have previously reported that Fe(II)tetrakis-N,N,N',N'-(2-pyridylmethyl)ethylenediamine (Fe(II)TPEN) has an excellent SOD activity (IC50=0.5 μM) among many iron complexes examined (J. Biol. Chem., 264, 9243-9249 (1989)). Fe(II)TPEN can act like native SOD in living cells, and protect Escherichia coli cells from free radical toxicity caused by paraquat. In order to develop more effective SOD functional mimics, we synthesized Fe(II)TPEN derivatives with electron-donating or electron-withdrawing groups at the 4-position of all pyridines of TPEN, and measured the SOD activities and the redox potentials of these complexes. Fe(II) tetrakis-N,N,N',N'-(4-methoxy-2-pyridylmethyl)ethylenediamine (Fe(II)(4MeO)4TPEN) had the highest SOD activity (IC50=0.1 μM) among these iron-based SOD mimics. In addition, a good correlation was found between the redox potential and the SOD activity of 15 Fe(II) complexes, including iron-based SOD mimics reported in the previous paper (J. Organometal. Chem., in press). Iron-based SOD mimics may be clinically applicable, because these complexes are generally tissue-permeable and show low toxicity. Therefore our findings should be significant for the development of clinically useful SOD mimics.