131748-92-0

Usage

Uses

Used in Pharmaceutical Industry:
2-BROMO-5-AMINOMETHYL-THIAZOLE HYDROCHLORIDE is used as a reagent for the preparation of CK2 inhibitors for the treatment of cancer. It plays a crucial role in the development of these inhibitors by providing a structural framework that can be further modified and optimized to enhance their potency and selectivity against cancer cells.
CK2 (Casein Kinase 2) is a serine/threonine protein kinase that has been implicated in various cellular processes, including cell proliferation, differentiation, and apoptosis. Overexpression or dysregulation of CK2 has been observed in several types of cancer, making it an attractive target for therapeutic intervention. By inhibiting CK2, these inhibitors can potentially disrupt the signaling pathways that promote cancer cell growth and survival, leading to the suppression of tumor progression.

Upstream product

• 131748-91-9 2-bromo-5-(bromomethyl)-1,3-thiazole 
• 917946-67-9 C₁₂H₇BrN₂O₂S 

Downstream Products

• 937662-94-7 C₆H₁₀N₂OS 

Relevant academic research and scientific papers

Synthesis, herbicidal activities, and 3D-QSAR of 2-cyanoacrylates containing aromatic methylamine moieties

A series of novel 2-cyanoacrylates containing different aromatic rings were synthesized, and their structures were characterized by 1H NMR, elemental analysis, and single-crystal X-ray diffraction analysis. Their herbicidal activities against four weeds and inhibition of photosynthetic electron transport against isolated chloroplasts (the Hill reaction) were evaluated. Both in vivo and in vitro data showed that the compounds containing benzene, pyridine, and thiazole moieties gave higher activities than those containing pyrimidine, pyridazine, furan, and tetrahedronfuran moieties. To further explore the comprehensive structure-activity relationship on the basis of in vitro data, comparative molecular field analysis (CoMFA) was performed, and the results showed that a bulky and electronegative group around the para-position of the aromatic rings would have the potential for higher activity, which offered important structural insights into designing highly active compounds prior to the next synthesis.

Guanidine derivatives, their production and insecticides

An insecticidal composition containing a guanidine derivative of the formula: STR1 wherein R1 is an optionally substituted homocyclic or heterocyclic group, n is 0 or 1, R2 is a hydrogen atom or an optionally substituted hydrocarbon group, R3 is a primary, secondary or tertiary amino group, X is an electron attractive group such as nitro or trifluoroacetyl group, provided that when n is 0, R1 is an optionally substituted heterocyclic group or a salt thereof.