13182-87-1

Basic information

• Product Name: [2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl] hydrogen succinate
• Synonyms: [2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl] hydrogen succinate;Metronidazolehemisuccinate;metronidazole monosuccinate;Butanedioic acid hydrogen 4-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl] ester;Butanedioic acid, mono(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl) ester;Einecs 236-130-1;4-[2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethoxy]-4-oxobutanoic acid
• CAS NO: 13182-87-1
• Molecular Formula: C₁₀H₁₃N₃O₆
• Molecular Weight: 271.22672
• EINECS: 236-130-1
• Mol File: 13182-87-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 555.6°C at 760 mmHg
• Flash Point: 289.8°C
• Appearance: /
• Density: 1.47g/cm³
• Vapor Pressure: 3.51E-13mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: [2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl] hydrogen succinate(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl] hydrogen succinate(13182-87-1)
• EPA Substance Registry System: [2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl] hydrogen succinate(13182-87-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 13182-87-1(Hazardous Substances Data)

Usage

General Description

[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl] hydrogen succinate is a chemical compound with the molecular formula C9H12N4O6. It is commonly used as an antiprotozoal and antibacterial agent, and is also used as a veterinary medicine. [2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl] hydrogen succinate is a member of the nitroimidazole class of drugs, which are characterized by their ability to selectively target and kill anaerobic microorganisms such as bacteria and protozoa. The hydrogen succinate salt form of this compound allows for improved solubility and stability, making it easier to formulate into various pharmaceutical preparations. This chemical is often used in the treatment of infections such as trichomoniasis, giardiasis, and other parasitic infections in both humans and animals.

InChI:InChI=1/C10H13N3O6/c1-7-11-6-8(13(17)18)12(7)4-5-19-10(16)3-2-9(14)15/h6H,2-5H2,1H3,(H,14,15)

Upstream product

• 108-30-5 succinic acid anhydride 
• 443-48-1 metronidazole 
• 13357-09-0 succinic acid bis-[2-(2-methyl-5-nitro-imidazol-1-yl)-ethyl] ester 
• 220819-23-8 1-(5,7-diiodoquinolin-8-yl)-4-<2-(2-methyl-5-nitro-1H-imidazolyl)ethyl>butandioate 
• 220819-20-5 1-(5-chloro-7-iodoquinolin-8-yl)-4-<2-(2-methyl-5-nitro-1H-imidazolyl)ethyl>butandioate 

Relevant articles and documents

Macromolecular prodrugs of metronidazole. 1. Esterification of hydroxyl containing polymers with metronidazole monosuccinate

-

Synthesis of fluorescent drug molecules for competitive binding assay based on molecularly imprinted polymers

Fluorescent immunosorbent assay (FIA) is very promising for sensitive and selective analysis in bio-medical applications. Here, we proposed an assay, using fluorescent engineering of analytes and the corresponding molecularly imprinted polymers (MIPs) as a plastic antibody. Three drug molecules (metronidazole, zidovudine and lamivudine) were condensed with 9-aminoacridine, using succinic anhydride as a spacer. The target products were characterized with 1H-NMR, IR and mass spectrometry. UV-vis absorption and fluorescent properties of the fluorophore-labeled drug molecules were investigated. Feasibility of the fluorescent biomimetic immunosorbent assay based on MIPs was demonstrated in the solution. This work will provide sound foundation for the future application in real sample.

Efficient acylation and one-pot synthesis of dehydroandrographolide succinate on a large scale assisted with microwave radiation

A rapid and convenient method for acylation and large-scale synthesis of dehydroandrographolide succinate has been developed under microwave irradiation. It is a one-pot condensation and is compatible with dehydration and rearrangement of double bond in mild reaction conditions with good yield, high purity (up to 99.8%), time-savings, few pollutants and low cost. In addition, a number of acylation derivatives were synthesized under microwave irradiation.