1318220-53-9Relevant academic research and scientific papers
Synthesis and antitubercular evaluation of amidoalkyl dibenzofuranols and 1H-benzo[2,3]benzofuro[4,5-e][1,3]oxazin-3(2H)-ones
Kantevari, Srinivas,Yempala, Thirumal,Yogeeswari, Perumal,Sriram, Dharmarajan,Sridhar, Balasubramanian
, p. 4316 - 4319 (2011)
A new class of amidoalkyl dibenzofuranols and 1H-benzo[2,3]benzofuro[4,5-e] [1,3]oxazin-3(2H)-ones was synthesized in very good yields through polyphosphoric acid supported on silica (PPA-SiO2) catalyzed one-pot three component condensation of 2-dibenzofuranol; aromatic aldehydes and acetamide or benzamide or urea under solvent free conditions. At 125 °C the reaction led to the formation of amidoalkyl dibenzofuranols 5a-k where as at 160 °C cyclization take place to give oxazin-3(2H)-one analogues 6a-e. Screening all the 16 compounds for in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv (MTB) resulted 1-((4-chlorophenyl)(2- hydroxydibenzo[b,d]furanyl)methyl)urea 5h; 1-((4-bromophenyl)(2- hydroxydibenzo[b,d]furanyl)methyl)urea 5i; 1-phenyl-1H-benzo[2,3]benzo furo[4,5-e][1,3]oxazin-3(2H)-one 6a (MIC 3.13 μg/mL) and 1-(4-chlorophenyl)- 1H-benzo[2,3]benzofuro[4,5-e][1,3]oxazin-3(2H)-one 6b; 1-(4-bromophenyl)-1H- benzo[2,3]benzofuro [4,5-e][1,3]oxazin-3(2H)-one 6c (MIC 1.56 μg/mL) as most active antitubercular agents.
Preparation of 1-amidoalkyl-2-naphthol derivatives using barium phosphate nano-powders
Taghrir, Hadi,Ghashang, Majid,Biregan, Mohammad Najafi
, p. 119 - 126 (2016/01/26)
Barium phosphate (Ba3(PO4)2) nano-powder was successfully synthesized via a simple precipitation route without any surfactant. The prepared nano-powder was applied for the facile synthesis of 1-amidoalkyl-2-naphthol derivatives using multi-component reaction of aldehydes, 2-naphthol and an amide (or urea) in high yields.
