1318240-22-0

Basic information

• Product Name: (S)-tert-butyl 2-(2-tolylmethyl)pyrrolidine-1-carboxylate
• Synonyms: (S)-tert-butyl 2-(2-tolylmethyl)pyrrolidine-1-carboxylate
• CAS NO: 1318240-22-0
• Molecular Weight: 275.391
• Mol File: 1318240-22-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-tert-butyl 2-(2-tolylmethyl)pyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-tert-butyl 2-(2-tolylmethyl)pyrrolidine-1-carboxylate(1318240-22-0)
• EPA Substance Registry System: (S)-tert-butyl 2-(2-tolylmethyl)pyrrolidine-1-carboxylate(1318240-22-0)

Safety Data

• Hazardous Substances Data: 1318240-22-0(Hazardous Substances Data)

Upstream product

• 615-37-2 ortho-methylphenyl iodide 
• 202925-92-6 N-Pent-4-enylcarbamic acid tert-butyl ester 
• 95-46-5 2-methylphenyl bromide 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 33872-80-9 o-tolyl magnesium chloride 
• 338945-22-5 (S)-2-iodomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 147-85-3 L-proline 
• 69610-40-8 N-(tert-butoxycarbonyl)-L-prolinol 

Relevant articles and documents

Cobalt-catalyzed carbon-carbon bond formation: Synthesis and applications of enantiopure pyrrolidine derivatives[1]

In the presence of cobalt catalysts and tetramethylethylenediamine (TMEDA), the iodine atom in (S)-2-(iodomethyl)pyrrolidines was replaced by an aryl or an alkynyl group from the corresponding Grignard reagent, and the coupling products were obtained in good to excellent yields (16 examples; 75-94% yields). The scope and limitations of this protocol were examined. The stereochemistry of the pyrrolidines was unaffected by the reaction conditions. The coupling products are important building blocks of phenanthroindolizidine alkaloids. Palladium-catalyzed formal [4+2] cycloaddition of 2,2′-diiodobiphenyl with the thus-generated (S)-2-(3-trimethylsilyl-2-propynyl)pyrrolidine gave a good yield of the desilylated phenanthrene, which was then converted into unnatural (+)-(S)-tylophorine by the Pictet-Spengler cyclization. Copyright