1318791-85-3Relevant academic research and scientific papers
Discovery of 2-(Imidazo[1,2- b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites
Krall, Jacob,Bavo, Francesco,Falk-Petersen, Christina B.,Jensen, Claus H.,Nielsen, Julie O.,Tian, Yongsong,Anglani, Valeria,Kongstad, Kenneth T.,Piilgaard, Louise,Nielsen, Birgitte,Gloriam, David E.,Kehler, Jan,Jensen, Anders A.,Harps?e, Kasper,Wellendorph, Petrine,Fr?lund, Bente
, p. 2798 - 2813 (2019/05/09)
Gabazine, a γ-aminobutyric acid type A (GABAA) receptor antagonist, has previously been reported to inhibit the binding of [3H]NCS-382, a representative ligand of the high-affinity binding site for the neuroactive substance γ-hydroxy
Synthesis and evaluation of highly potent GABAA receptor antagonists based on gabazine (SR-95531)
Iqbal, Favaad,Ellwood, Ryan,Mortensen, Martin,Smart, Trevor G.,Baker, James R.
, p. 4252 - 4254 (2011/08/06)
A selection of highly potent analogues based on the gabazine structure is described. Their syntheses are carried out in just four steps, and their potencies for antagonism at the GABAA receptor were measured. All antagonists showed significantly higher potencies compared to the parent competitive antagonist, gabazine.
