131887-48-4

Basic information

• Product Name: 2-benzylmorpholine
• Synonyms: 2-benzylmorpholine
• CAS NO: 131887-48-4
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.24
• Mol File: 131887-48-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 284.1°Cat760mmHg
• Flash Point: 112.3°C
• Appearance: /
• Density: 1.031g/cm³
• Vapor Pressure: 0.00304mmHg at 25°C
• Refractive Index: 1.523
• PKA: 8.97±0.40(Predicted)
• CAS DataBase Reference: 2-benzylmorpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzylmorpholine(131887-48-4)
• EPA Substance Registry System: 2-benzylmorpholine(131887-48-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 131887-48-4(Hazardous Substances Data)

Usage

General Description

2-Benzylmorpholine is a chemical compound with the molecular formula C13H17NO. It is a morpholine derivative that is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It possesses a benzyl group attached to the morpholine ring, giving it unique properties and potential applications in various industries. It is also used as a solvent and as an intermediate in organic synthesis. The compound is known for its low toxicity and relatively low environmental impact, making it a favorable choice for manufacturing processes. Additionally, 2-benzylmorpholine is also used in research and development as a starting material for the synthesis of new compounds with potential biological activities.

InChI:InChI=1/C11H15NO/c1-2-4-10(5-3-1)8-11-9-12-6-7-13-11/h1-5,11-12H,6-9H2

Upstream product

• 300-57-2 allylbenzene 
• 4436-24-2 1,2-epoxy-3-phenylpropane 
• 66820-58-4 2-bromo-3-phenylpropan-1-ol 
• 87955-28-0 2(RS)-(phenylmethyl)morpholine 
• 100-58-3 phenylmagnesium bromide 
• 926-39-6 sulfuric acid mono-(2-amino-ethyl ester) 
• 5396-65-6 1-chloro-3-phenylpropan-2-ol 
• 1234549-58-6 tert-butyl 2-benzylmorpholine-4-carboxylate 

Downstream Products

• 87955-28-0 (+)-2-benzylmorpholine 
• 87955-28-0 (-)-2-benzylmorpholine 
• 1598382-88-7 (4-chlorophenyl)-carbamic acid (S)-1-((R)-2-benzyl-morpholin-4-ylmethyl)-2,2,2-trifluoro-ethyl ester 
• 1598382-87-6 (S)-3-(2-benzylmorpholin-4-yl)-1,1,1-trifluoro-propan-2-ol 

Relevant articles and documents

A Concise Stereoselective Synthesis of (R)-2-Benzylmorpholine and ML398 from (R)-(?)-2-Phenylglycinol

We describe here an efficient stereoselective method for the preparation of (R)-2-benzylmorpholine and ML398. The present method features a high diastereocontrol using an endocyclic oxidation of phenylglycinol-derived morpholine and a stereoselective alky

COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR

Compounds are provided which bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, the compounds having the general formula (I) wherein, R1, R2, A, Y, X, Ar1 and Ar2 have the meanings given in the specification, and the preparation and use thereof. The compounds are valuable CB2 receptor modulators.

Synthesis and resolution of the novel appetite suppressant 2-benzylmorpholine, a nonstimulant isomer of phenmetrazine

The synthesis of 2-benzylmorpholine from allylbenzene together with its resolution into its (+)- and (-)-enantiomers is reported. Oral dosing of the racemate to dogs caused appetite suppression with an ED50 of 3 and 5.5 mg kg-1 at 1 and 2 h, re