13195-80-7

Basic information

• Product Name: 1,1-DIBROMO-1-PROPENE
• Synonyms: 1,1-DIBROMO-1-PROPENE;1,1-dibromo-1-propen;1,1-dibromopropene;1-Propene, 1,1-dibromo-;1,1-DIBROMO-1-PROPENE: TECH., 90%;Einecs 236-162-6
• CAS NO: 13195-80-7
• Molecular Formula: C₃H₄Br₂
• Molecular Weight: 199.87
• EINECS: 236-162-6
• Mol File: 13195-80-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 126-128°C
• Flash Point: 9.9 °C
• Appearance: /
• Density: 1.9767
• Vapor Pressure: 13.6mmHg at 25°C
• Refractive Index: 1.5260
• CAS DataBase Reference: 1,1-DIBROMO-1-PROPENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-DIBROMO-1-PROPENE(13195-80-7)
• EPA Substance Registry System: 1,1-DIBROMO-1-PROPENE(13195-80-7)

Safety Data

• Statements: 10-36/37/38
• Safety Statements: 16-26-36
• RIDADR: 1993
• Hazardous Substances Data: 13195-80-7(Hazardous Substances Data)

Usage

General Description

1,1-Dibromo-1-propene, also known as 1,1-dibromopropene, is a colorless liquid compound with a molecular formula of C3H4Br2. It is classified as an unsaturated halogenated hydrocarbon and is mainly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is a highly reactive compound due to the presence of the double bond, making it susceptible to addition reactions with a variety of reagents. It is also considered to be moderately toxic and a potential environmental hazard due to its persistence in the environment and potential for bioaccumulation in aquatic organisms. Overall, 1,1-dibromo-1-propene is an important chemical intermediate that requires careful handling and management to minimize its potential impact on human health and the environment.

InChI:InChI=1/C3H4Br2/c1-2-3(4)5/h2H,1H3

Upstream product

• 153736-33-5 2,2,3-tribromo-butyric acid 
• 7732-18-5 water 
• 558-13-4 carbon tetrabromide 
• 75-07-0 acetaldehyde 
• 3132-64-7 1,2-Epoxy-3-bromopropane 
• 2003-82-9 3-bromo-2-propyne 
• 10035-10-6 hydrogen bromide 
• 109-66-0 pentane 
• 603-35-0 triphenylphosphine 
• 58577-57-4 1,1,1-tribromo-propan-2-ol 
• 73383-18-3 1,1,1-tribromo-2-methoxy-propane 
• 73383-12-7 1,1-dibromo-2-methoxy-propane 
• 118020-42-1 1,1-dibromo-3-iodo-propene 
• 153736-32-4 2,2,3-tribromo-butyraldehyde 

Downstream Products

• 764-01-2 methyl propargyl alcohol 
• 2003-82-9 3-bromo-2-propyne 
• 1174638-52-8 N-benzyl-4-methyl-N-(prop-1-yn-1-yl)benzenesulfonamide 
• 187737-37-7 propene 
• 74-99-7 prop-1-yne 
• 14602-62-1 1,1,2-tribromo-propane 
• 563-76-8 α-bromopropionyl bromide 
• 110-81-6 Diethyl disulfide 
• 598-72-1 2-Bromopropionic acid 

Relevant articles and documents

Total Synthesis of Gelsenicine via a Catalyzed Cycloisomerization Strategy

The first total synthesis of (±)-gelsenicine is reported. The synthetic route is highly efficient (13 steps), featuring (1) a pivotal metal-catalyzed isomerization/rearrangement process that forges the central core of the molecule and (2) two facile C-N bond-forming steps that establish the flanking heterocycles.

Benzannulation of triynes to generate functionalized arenes by spontaneous incorporation of nucleophiles

The thermal reaction of ester-tethered 1,3,8-triynes provides novel benzannulation products with concomitant incorporation of a nucleophile. Evidence suggests that this reaction proceeds via an allene-enyne intermediate generated by an Alder-ene reaction in the first step. Depending on the substituent of the alkyne moiety on the allene-enyne intermediate, the subsequent transformation can take one of two different paths, each leading to discrete aromatization products. The benzannulation of a silane-substituted 1,3,8-triynes provides arene products with a nucleophile incorporated onto the newly formed benzene core, whereas an aryl substituent leads to nucleophile trapping at the benzylic carbon atom connected to the aryl substituent. The formation of these two different products results from the involvement of two regioisomeric allene-enyne intermediates.

Preparation of epoxides

This invention is a process for the preparation of an epoxide which comprises contacting a 2-haloalkyl or 2,3-dihaloalkyl carbonate, bis(2-haloalkyl- or 2,3-dihaloalkyl)carbonate, or 2-haloalkyl or 2,3-dihaloalkyl ester dissolved in a water-miscible alcohol with a sufficient amount of an aqueous solution of an alkali metal or alkaline earth metal hydroxide to provide at least one equivalent of alkali metal or alkaline earth metal hydroxide per equivalent of ester or carbonate, at a temperature of between about 0° C. and 70° C. under conditions such that an epoxide is prepared.