131965-54-3Relevant academic research and scientific papers
Surfactant-accelerated asymmetric transfer hydrogenation with recyclable water-soluble catalyst in aqueous media
Li, Jiahong,Li, Xuefeng,Ma, Yaping,Wu, Jiashou,Wang, Fei,Xiang, Jing,Zhu, Jin,Wang, Qiwei,Deng, Jingen
, p. 1825 - 1834 (2013/03/14)
Water-soluble ligands (R,R)-2 were successfully prepared, in which the bis-meta-sulphonated ligand was definitely detected as the major product. The corresponding transition-metal complexes containing the ligands displayed excellent catalytic performance in asymmetric transfer hydrogenation (ATH) of aromatic ketones. Especially, the aromatic ketones with a bromine group in the α position could be smoothly reduced to the expected alcohol, keeping the bromine group intact with excellent enantioselectivities (up to 96% ee). The catalyst could be reused at least 21 times without erosion of the enantioselectivity in high conversion. Moreover, it was found that cationic surfactant and proper pH values were necessary for the maintenance of high reactivity.
Chemoenzymatic synthesis of enantiopure 1-phenyl-2-haloethanols and their esters
Lystvet, Sina Maria,Hoff, Bard Helge,Anthonsen, Thorleif,Jacobsen, Elisabeth Egholm
experimental part, p. 272 - 278 (2011/11/30)
Several secondary haloalcohols have been resolved by esterification catalyzed by lipases A and B from Candida antarctica (CALA and CALB, respectively). Immobilized CALB (Novozym 435) gave better selectivities and faster reaction rates than CALA (Novozyme
Asymmetric transfer hydrogenation of ketones catalyzed by hydrophobic metal-amido complexes in aqueous micelles and vesicles
Wang, Fei,Liu, Hui,Cun, Linfeng,Zhu, Jin,Deng, Jingen,Jiang, Yaozhong
, p. 9424 - 9429 (2007/10/03)
Asymmetric transfer hydrogenation of ketones, especially α-bromomethyl aromatic ketones, catalyzed by unmodified, hydrophobic transition metal-amido complexes (TsDPEN-M), was performed successfully with significant enhancement of activity, chemoselectivity, and enantio-selectivity (up to 99% ee) in aqueous media containing micelles and vesicles. The hydrophobic catalyst, embedded in micelles constructed from the surfactant cetyltrimethylammonium bromide (CTAB), could be separated from the organic phase along with the products and was recycled for at least six times.
A convenient stereoselective synthesis of (R)-(-)-denopamine and (R)-(-)-salmeterol
Goswami, Jonali,Bezbaruah, Rajiv L.,Goswami, Amrit,Borthakur, Naleen
, p. 3343 - 3348 (2007/10/03)
β-Adrenoreceptor agonists (R)-(-)-denopamine (R)-1 and (R)-(-)-salmeterol (R)-2 have been prepared in good overall yield and high enantioselectivity through a biotransformative pathway.
Microbial reduction of ω-bromoacetophenones in the presence of surfactants
Goswami,Bezbaruah,Goswami,Borthakur,Dey,Hazarika
, p. 3701 - 3709 (2007/10/03)
Several ω-bromoacetophenone derivatives 6a-f were reduced to (R)-(-)-2-bromo-1-(phenyl/substituted phenyl) ethanol derivatives 7a-f with whole cell biocatalysts in good yields. The enantiomeric excesses were increased to 95% using an anionic surfactant under an inert atmosphere in an aqueous medium. Copyright (C) 2000 Elsevier Science Ltd.
1,2-ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same
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, (2008/06/13)
This invention relates to a 1,2-ethanediol derivative and a salt thereof, a process for producing the same, and a cerebral function improving agent comprising the same. The cerebral function-improving agent of this invention is useful for treating cerebrovascular dementia, senile dementia, Alzheimer's dementia, sequelae of ischemic encephalopathy and cerebral apoplexy.
