131968-74-6 Usage
Uses
Used in Pharmaceutical Industry:
(2R,3S)-3-phenylisoserine methyl ester is utilized as a key intermediate in the synthesis of various pharmaceuticals due to its unique structural features. Its chiral center and phenyl group allow for the creation of complex molecules with specific biological activities, contributing to the development of innovative treatments.
Used in Medicinal Chemistry Research:
In the realm of medicinal chemistry, (2R,3S)-3-phenylisoserine methyl ester serves as a valuable compound for the exploration of new drug candidates. Its structural attributes make it an ideal starting point for the design and synthesis of molecules with potential therapeutic applications, thereby advancing the discovery of novel pharmaceuticals.
Used in Biologically Active Compounds Synthesis:
(2R,3S)-3-phenylisoserine methyl ester is employed as a synthetic building block in the production of biologically active compounds. Its incorporation into these compounds can enhance their efficacy, selectivity, or stability, making it a crucial component in the development of next-generation bioactive substances.
Check Digit Verification of cas no
The CAS Registry Mumber 131968-74-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,9,6 and 8 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 131968-74:
(8*1)+(7*3)+(6*1)+(5*9)+(4*6)+(3*8)+(2*7)+(1*4)=146
146 % 10 = 6
So 131968-74-6 is a valid CAS Registry Number.
InChI:InChI=1/C10H13NO3/c1-14-10(13)9(12)8(11)7-5-3-2-4-6-7/h2-6,8-9,12H,11H2,1H3/t8-,9+/m0/s1
131968-74-6Relevant academic research and scientific papers
Synthesis of β-amino α-hydroxy carboxylic esters from oxiranecarboxylic esters
Legters, Johan,Dienst, Erik van,Thijs, Lambertus,Zwanenburg, Binne
, p. 69 - 74 (2007/10/02)
3-Aryl-3-azido-2-hydroxypropanoic esters, prepared from the corresponding 3-aryl-oxirane-2-carboxylic esters by ring opening with sodium azide, were reduced with tin(II) chloride dihydrate in methanol to give 3-amino-3-aryl-2-hydroxypropanoic esters in good yields.Under these conditions, halogen substituents in the aromatic rings were not affected.The nitro group, however, was partially reduced to the amino group.Treatment of aliphatic oxirane-2-carboxylic esters with acetonitrile in the presence of boron trifluoride etherate led to regiospecific formation of 2,4-dialkyl-2-oxazoline-5-carboxylic esters, resulting from reaction of the nitrile at C3.Acidic hydrolysis of these oxazoline-5-carboxylic esters gave the corresponding 3-(acylamino)-2-hydroxy carboxylic esters.With these two complementary methods, both aryl- and alkyl-substituted β-amino α-hydroxy acid derivatives are accessible.
Highly stereoselective synthesis of α-hydroxy β-amino acids through β-lactams: Application to the synthesis of the taxol and bestatin side chains and related systems
Palomo,Arrieta,Cossio,Aizpurua,Mielgo,Aurrekoetxea
, p. 6429 - 6432 (2007/10/02)
Formation of α-hydroxy β-lactams, followed by chemical elaboration at C4 and further β-lactam cleavage afforded functionalised α-hydroxy β-amino acids or their derivatives in a highly stereoselective manner.
