13201-14-4 Usage
Uses
Used in Pharmaceutical Industry:
(10α)-25-(Acetyloxy)-2β,16α,20-trihydroxy-9β-methyl-19-norlanost-5-ene-3,11,22-trione is used as a pharmaceutical agent for its anti-inflammatory properties, helping to reduce inflammation and alleviate symptoms associated with various inflammatory conditions.
Used in Anticancer Applications:
In the field of oncology, (10α)-25-(Acetyloxy)-2β,16α,20-trihydroxy-9β-methyl-19-norlanost-5-ene-3,11,22-trione is utilized as an anticancer agent, targeting various types of cancer cells and exhibiting inhibitory effects on tumor growth and progression. Its unique structure allows it to modulate multiple oncological signaling pathways, making it a valuable asset in the development of novel cancer therapies.
Used in Drug Delivery Systems:
To enhance the efficacy and bioavailability of (10α)-25-(Acetyloxy)-2β,16α,20-trihydroxy-9β-methyl-19-norlanost-5-ene-3,11,22-trione, various drug delivery systems have been developed. These systems, including organic and metallic nanoparticles, serve as carriers for the compound, improving its delivery to target cells and tissues, and enhancing its therapeutic outcomes.
Used in Cosmetic Industry:
(10α)-25-(Acetyloxy)-2β,16α,20-trihydroxy-9β-methyl-19-norlanost-5-ene-3,11,22-trione is used as an active ingredient in cosmetic products for its anti-inflammatory and anti-microbial properties. It can help soothe irritated skin, reduce redness, and protect against harmful microorganisms, making it suitable for skincare formulations.
Used in Agricultural Industry:
In agriculture, (10α)-25-(Acetyloxy)-2β,16α,20-trihydroxy-9β-methyl-19-norlanost-5-ene-3,11,22-trione is employed as a natural antimicrobial agent to protect crops from various diseases and pests. Its unique structure allows it to target and inhibit the growth of harmful microorganisms, promoting healthy plant growth and increasing crop yields.
Check Digit Verification of cas no
The CAS Registry Mumber 13201-14-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,2,0 and 1 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 13201-14:
(7*1)+(6*3)+(5*2)+(4*0)+(3*1)+(2*1)+(1*4)=44
44 % 10 = 4
So 13201-14-4 is a valid CAS Registry Number.
InChI:InChI=1/C32H48O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,19-22,25,34-35,39H,11-16H2,1-9H3/t19-,20+,21-,22+,25+,29+,30-,31+,32+/m1/s1
13201-14-4Relevant academic research and scientific papers
Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery
Hall, Jessica A.,Seedarala, Sahithi,Rice, Nichole,Kopel, Lucas,Halaweish, Fathi,Blagg, Brian S. J.
, p. 873 - 879 (2015/05/13)
Heat shock protein 90 (Hsp90) facilitates the maturation of many newly synthesized and unfolded proteins (clients) via the Hsp90 chaperone cycle, in which Hsp90 forms a heteroprotein complex and relies upon cochaperones, immunophilins, etc., for assistance in client folding. Hsp90 inhibition has emerged as a strategy for anticancer therapies due to the involvement of clients in many oncogenic pathways. Inhibition of chaperone function results in client ubiquitinylation and degradation via the proteasome, ultimately leading to tumor digression. Small molecule inhibitors perturb ATPase activity at the N-terminus and include derivatives of the natural product geldanamycin. However, N-terminal inhibition also leads to induction of the pro-survival heat shock response (HSR), in which displacement of the Hsp90-bound transcription factor, heat shock factor-1, translocates to the nucleus and induces transcription of heat shock proteins, including Hsp90. An alternative strategy for Hsp90 inhibition is disruption of the Hsp90 heteroprotein complex. Disruption of the Hsp90 heteroprotein complex is an effective strategy to prevent client maturation without induction of the HSR. Cucurbitacin D, isolated from Cucurbita texana, and 3-epi-isocucurbitacin D prevented client maturation without induction of the HSR. Cucurbitacin D also disrupted interactions between Hsp90 and two cochaperones, Cdc37 and p23.
CUCURBITACINS AND FLAVONE C-GLYCOSIDES FROM CAYAPONIA TAYUYA
Bauer, Rudolf,Berganza, Luis H.,Seligmann, Otto,Wagner, Hildebert
, p. 1587 - 1592 (2007/10/02)
Key Word Index - Cayaponia tayuya; Cucurbitaceae; cucurbitacin B; cucurbitacin R; 23,24-dihydrocucurbitacin B; 23,24-dihydroxyisocucurbitacin B; cucurbitacin glycosides; flavone C-glycosides; HPLC. - From the roots of Cayaponia tayuya seven cucurbitacins have been isolated by HPLC and identified mainly by MS as cucurbitacin R-glucoside, cucurbitacin R, 23,24-dihydrocucurbitacin B-glucoside, 23,24-dihydrocucurbitacin B, 23,24-dihydroisocucurbitacin B, cucurbitacin B and its 2-O-glucoside.In addition, the flavone C-glucosides swertisin, spinosin, vicenin-2, vitexin, isovitexin, orientin and isoorientin have been isolated.
