1374959-38-2

Basic information

• Product Name: C₃₉H₅₂O₉
• Synonyms: C₃₉H₅₂O₉
• CAS NO: 1374959-38-2
• Molecular Weight: 664.836
• Mol File: 1374959-38-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₃₉H₅₂O₉(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₉H₅₂O₉(1374959-38-2)
• EPA Substance Registry System: C₃₉H₅₂O₉(1374959-38-2)

Safety Data

• Hazardous Substances Data: 1374959-38-2(Hazardous Substances Data)

Upstream product

• 6798-81-8 23,24-dihydrocucurbitacin B 
• 93-97-0 benzoic acid anhydride 
• 98-88-4 benzoyl chloride 

Relevant articles and documents

Lipid-Lowering Activities of Cucurbitacins Isolated from Trichosanthes cucumeroides and Their Synthetic Derivatives

In the ongoing efforts to discover natural cholesterol-lowering compounds, dihydrocucurbitacin B, isolated from Trichosanthes cucumeroides roots, was found to promote LDL uptake by upregulating LDLR protein in a PCSK9-dependent process. In this study, an in-depth investigation of T. cucumeroides roots afforded 27 cucurbitacins (1-27), including seven new cucurbitacins (1-7), and their structures were elucidated by spectroscopic data analyses. In order to gain insight into their structure-activity relationship, cucurbitacin derivatives (B1-11 and DB1-11) were synthesized. Evaluation of lipid-lowering activities of these cucurbitacins by an LDL uptake assay in HepG2 cells revealed that most of the compounds improved the LDL uptake rate, among which hexanorisocucurbitacin D (6) and isocucurbitacin D (21) exhibited the highest activities (rates of 2.53 and 2.47, respectively), which were comparable to that of the positive control, nagilactone B (rate of 2.07). According to a mechanistic study by Western blot analysis, compounds 6 and 21 dose-dependently increased LDLR protein levels and reduced PCSK9 protein levels, representing promising new lipid-lowering drug candidates.