20349-86-4

Basic information

• Product Name: Benzenepropanoic acid, 2-hydroxy-b-oxo-, methyl ester
• CAS NO: 20349-86-4
• Molecular Formula: C10H10O4
• Molecular Weight: 194.187
• Mol File: 20349-86-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, 2-hydroxy-b-oxo-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, 2-hydroxy-b-oxo-, methyl ester(20349-86-4)
• EPA Substance Registry System: Benzenepropanoic acid, 2-hydroxy-b-oxo-, methyl ester(20349-86-4)

Safety Data

• Hazardous Substances Data: 20349-86-4(Hazardous Substances Data)

Usage

General Description

Benzenepropanoic acid, 2-hydroxy-?-oxo-, methyl ester, also known as methyl 2-hydroxy-2-phenylacetate, is a chemical compound used in the production of various pharmaceuticals and fragrance ingredients. It is commonly used as a fragrance in personal care products and cosmetics. The compound has been shown to have potential antioxidant and anti-inflammatory properties, making it of interest for research in the development of new drugs and healthcare products. As a methyl ester, it is also used as a flavoring agent in food products. However, care must be taken when handling this chemical, as it can cause skin and eye irritation, and should only be used in well-ventilated areas and with proper personal protective equipment.

Upstream product

• 102-52-3 malonaldehydebis(dimethylacetal) 
• 102342-54-1 1,3,5-tris(trimethylsiloxy)-1-methoxyhexa-1,3,5-triene 
• 118-93-4 o-hydroxyacetophenone 
• 616-38-6 carbonic acid dimethyl ester 
• 425686-45-9 methyl 3-(2-hydroxyphenyl)propiolate 
• 533-58-4 2-Iodophenol 

Downstream Products

• 132018-11-2 3-(methoxycarbonyl)-2-(4-nitrophenyl)-4H-benzopyran-4-one 
• 4139-73-5 4-hydroxy-3-propanoyl-2H-1-benzopyran-2-one 
• 129410-02-2 methyl 2-ethyl-4-oxo-4H-1-benzopyran-3-carboxylate 
• 132018-05-4 2-(3,4-dimethoxyphenyl)-3-(methoxycarbonyl)-4H-benzopyran-4-one 
• 19725-49-6 4'-nitroflavone 
• 67858-30-4 2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one 
• 19093-64-2 4'-Aminoflavone 
• 4143-63-9 4'-hydroxyflavone 
• 132018-21-4 2-(4-hydroxyphenyl)-4-oxo-4H-benzopyran-3-carboxylic acid 
• 132018-17-8 2-(4-bromophenyl)-4-oxo-4H-benzopyran-3-carboxylic acid 
• 119586-00-4 2-(4-methoxyphenyl)-4-oxo-4H-benzopyran-3-carboxylic acid 
• 132018-15-6 3',5'-dimethoxy-4'-hydroxyflavone 
• 132018-26-9 2-(4-aminophenyl)-3-(methoxycarbonyl)-4H-benzopyran-4-one 
• 132018-23-6 2-(4-hydroxyphenyl)-3-(methoxycarbonyl)-4H-benzopyran-4-one 

Relevant articles and documents

Studies toward the Total Synthesis of Arylnaphthalene Lignans via a Photo-Dehydro-Diels-Alder (PDDA) Reaction

An efficient method for the preparation of arylnaphthalene lignans (ANLs) was developed, which is based on the Photo-Dehydro-Diels-Alder (PDDA) reaction. While intermolecular PDDA reactions turned out to be inefficient, the intramolecular variant using suberic acid as tether linking two aryl propiolic esters smoothly provided naphthalenophanes. The irradiations were performed with a previously developed annular continuous-flow reactor and UVB lamps. In this way, the natural products Alashinol D, Taiwanin C, and an unnamed ANL could be prepared.

A 5C + 5C Bicycloaromatization Reaction via an Aldol Condensation Cascade: A Regioselective Synthesis of Functionalized Naphthalenes from Acyclic Precursors

A regioselective synthesis of naphthalene derivatives 51 was developed by the reaction of 1,3,5-tris(trimethylsiloxy)-1-methoxyhexa-1,3,5-triene (2) with the 1,3,5-tris-electrophiles 50 and trimethylsilyl triflate.Three carbon-carbon bonds are formed in this aldol condensation cascade, where the regiochemistry is controlled by the different reactivities at the sites of the acyclic precursors.