132019-93-3Relevant academic research and scientific papers
An Efficient Synthesis of the Naphthalene Subunits of the Protein Kinase C Inhibitor Calphostin C
Coleman, Robert S.,Grant, Eugene B.
, p. 1357 - 1359 (2007/10/02)
An efficient synthesis of bromonaphthalenes 5b-c, which represent suitably functionalized precursors to the perylenequinone ring system characteristic of the protein kinase C inhibitor calphostin C (1), is described and was based on the Diels-Alder reaction of o-quinol acetate 7 with 1,1,3-trioxygenated butadienes 6a-c, followed by selective, acid-promoted elimination of R3SiOH and AcOH to directly afford naphthalenes 11a-c.
