2169-23-5Relevant academic research and scientific papers
POLYCYCLIC AMIDES AS UBE2K MODULATORS FOR TREATING CANCER
-
Paragraph 00180-00182; 00200-00202, (2021/07/10)
Provided are compounds of Formula (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating conditions associated with modulation of UBE2K.
Design of a Functional Chromene-Type Kobayashi Precursor: Gram-Scale Total Synthesis of Natural Xanthones by Highly Regioselective Aryne Annulation
Xu, Yuan-Ze,Sha, Feng,Wu, Xin-Yan
supporting information, p. 1066 - 1071 (2020/12/18)
The 2,2-dimethyl-2H-chromene motif is widely found in many bioactive molecules, and is a privileged structure in the pharmaceutical arena. We have developed a concise and regioselective approach to chromenes and chromanes through an aryne-based synthetic
Facile synthesis of salmochelin S1, S2, MGE, DGE, and TGE
Yu, Xiaolong,Dai, Yijing,Yang, Tao,Gagné, Michel R.,Gong, Hegui
supporting information; experimental part, p. 144 - 151 (2011/03/17)
Salmochelin S1, S2, MGE, DGE, and TGE were prepared through amide bond connection of an aryl C-glucosyl acyl chloride (Ar1COCl) and serine ester amines, followed by hydrogenolysis of the per-benzylated precursors. Each synthesis employed a highly diastereoselective Ni-catalyzed Negishi approach to the aryl C-glycoside subunit.
An Efficient Synthesis of the Naphthalene Subunits of the Protein Kinase C Inhibitor Calphostin C
Coleman, Robert S.,Grant, Eugene B.
, p. 1357 - 1359 (2007/10/02)
An efficient synthesis of bromonaphthalenes 5b-c, which represent suitably functionalized precursors to the perylenequinone ring system characteristic of the protein kinase C inhibitor calphostin C (1), is described and was based on the Diels-Alder reaction of o-quinol acetate 7 with 1,1,3-trioxygenated butadienes 6a-c, followed by selective, acid-promoted elimination of R3SiOH and AcOH to directly afford naphthalenes 11a-c.
