1320194-99-7Relevant academic research and scientific papers
Synthesis of carboxy-polyethylene glycol-amine (CA (PEG)n) and [1-14C]-CA (PEG)n via oxa-Michael addition of amino-polyethylene glycols to propiolates vs to acrylates
Song, Fengbin,Chen, Lu,Lin, Ronghui,Salter, Rhys
, p. 15 - 24 (2020)
Synthesis of carboxy-polyethylene glycol-amine (CA (PEG)n) via oxa-Michael addition of amino-polyethylene glycols to either acrylates or propiolates was investigated. Compared with the oxa-Michael addition to acrylates, the corresponding addition to propiolates was found to proceed under mild reaction conditions and afford the adducts in high yields from a broad scope of substrates. A two-step efficient and convenient synthesis of benzyl [1-14C]-propiolate from 14CO2 was therefore developed and utilized as a common synthon to afford practical and high yielding access to [1-14C]-CA (PEG)n.
An immobilized and reusable Cu(i) catalyst for metal ion-free conjugation of ligands to fully deprotected oligonucleotides through click reaction
Eltepu, Laxman,Jayaraman, Muthusamy,Rajeev, Kallanthottathil G.,Manoharan, Muthiah
supporting information, p. 184 - 186 (2013/02/23)
Chelation of Cu(i) ions to an immobilized hydrophilic tris(triazolylmethyl) amine chelator on a solid support allowed synthesis of RNA oligonucleotide conjugates from completely deprotected alkyne-oligonucleotides. No oligonucleotide strand degradation or metal ion contamination was observed. Furthermore, use of the immobilized copper(i) ion overcame regioselectivity issues associated with strain-promoted copper-free azide-alkyne cycloaddition. This journal is The Royal Society of Chemistry.
