1320195-00-3Relevant academic research and scientific papers
An immobilized and reusable Cu(i) catalyst for metal ion-free conjugation of ligands to fully deprotected oligonucleotides through click reaction
Eltepu, Laxman,Jayaraman, Muthusamy,Rajeev, Kallanthottathil G.,Manoharan, Muthiah
supporting information, p. 184 - 186 (2013/02/23)
Chelation of Cu(i) ions to an immobilized hydrophilic tris(triazolylmethyl) amine chelator on a solid support allowed synthesis of RNA oligonucleotide conjugates from completely deprotected alkyne-oligonucleotides. No oligonucleotide strand degradation or metal ion contamination was observed. Furthermore, use of the immobilized copper(i) ion overcame regioselectivity issues associated with strain-promoted copper-free azide-alkyne cycloaddition. This journal is The Royal Society of Chemistry.
