1320361-74-7

Basic information

• Product Name: ethyl 3-(4-bromoanilino)propenoate
• Synonyms: ethyl 3-(4-bromoanilino)propenoate
• CAS NO: 1320361-74-7
• Molecular Weight: 270.126
• Mol File: 1320361-74-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl 3-(4-bromoanilino)propenoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(4-bromoanilino)propenoate(1320361-74-7)
• EPA Substance Registry System: ethyl 3-(4-bromoanilino)propenoate(1320361-74-7)

Safety Data

• Hazardous Substances Data: 1320361-74-7(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 106-40-1 4-bromo-aniline 
• 623-47-2 propynoic acid ethyl ester 

Downstream Products

• 1320361-51-0 6-bromo-1-methyl-3-phenylquinolin-4(1H)-one 
• 1320361-52-1 6-bromo-1-methyl-3-(4-methylphenyl)quinolin-4(1H)-one 
• 1320361-56-5 6-bromo-3-[(E)-2-(4-methoxyphenyl)ethen-1-yl]-1-methylquinolin-4(1H)-one 
• 1320361-57-6 6-bromo-1-ethyl-3-(4-methylphenyl)quinolin-4(1H)-one 
• 1320361-58-7 6-bromo-3-(4-chlorophenyl)-1-cyclopropylmethylquinolin-4(1H)-one 
• 1320361-32-7 1-methyl-3-phenyl-6-[(4-trifluoromethoxy)phenyl]quinolin-4(1H)-one 
• 1320361-33-8 1-methyl-3-phenyl-6-(pyridin-3-yl)quinolin-4(1H)-one 
• 1320361-34-9 6-(3-chlorophenyl)-1-methyl-3-phenylquinolin-4(1H)-one 
• 1320361-35-0 6-(4-cyanophenyl)-1-methyl-3-(4-methylphenyl)quinolin-4(1H)-one 
• 1320361-36-1 6-(3-chlorophenyl)-3-(furan-2-yl)-1-methylquinolin-4(1H)-one 
• 1320361-38-3 6-(3-chlorophenyl)-3-[(E)-2-(4-methoxyphenyl)ethen-1-yl]-1-methylquinolin-4(1H)-one 
• 1320361-39-4 6-(3-chlorophenyl)-1-ethyl-3-(4-methylphenyl)quinolin-4(1H)-one 
• 1320361-42-9 6-(4-cyanophenyl)-1-methyl-3-(trimethylsilylethynyl)quinolin-4(1H)-one 
• 1320361-45-2 6-(3-chlorophenyl)-1-methyl-N-phenylquinolin-4(1H)-one-3-carboxamide 

Relevant articles and documents

6-bromo-4-chloroquinoline preparation method

The invention discloses a 6-bromo-4-chloroquinoline preparation method. 4-bromaniline, ethyl propiolate, phosphorus trichloride and the like are used as raw materials to obtain a target product 6-bromo-4-chloroquinoline through three-step reaction. The 6-bromo-4-chloroquinoline preparation method is convenient and simple in operation and environment friendly, the comprehensive yield is 70% or above and remarkably increased as compared with existing yield which is 26-42%, existing medicine production cost is sharply reduced, and the 6-bromo-4-chloroquinoline preparation method is suitable for industrial mass production.

Regioselective functionalization of quinolin-4(1H)-ones via sequential palladium-catalyzed reactions

A practical and general synthesis of 1,3,6-trisubstituted quinolin-4(1H)-ones starting from 1-alkyl-6-bromo-3-iodoquinolin-4(1H)-one is described, based on regioselective sequential palladium-catalyzed cross-coupling reactions, namely Suzuki-Miyaura, Sono