132059-13-3

Upstream product

• 603-85-0 2-Amino-3-nitrophenol 
• 113826-06-5 (R)-glycidyl tosylate 
• 70987-78-9 (S)-Glycidyl tosylate 
• 115314-14-2 (2s)-(+)-glycidyl 3-nitrobenzenesulfonate 
• 115314-14-2 (R)-glycidyl nosylate 

Downstream Products

• 142204-75-9 S-<1-(2,3-diaminophenoxy)>-3'-(N-t-butylamino)propan-2'-ol 
• 132059-14-4 S-<1-(2-amino-3-nitrophenoxy)>-3'-(N-t-butylamino)propan-2'-ol 
• 132059-12-2 R-<1-(2-amino-3-nitrophenoxy)>-3'-(N-t-butylamino)propan-2'-ol 

Relevant academic research and scientific papers

Azolidines as beta-3 adrenergic receptor agonists

This invention provides compounds of Formula I having the structure wherein, A, X, Y, Z, W, R1, R2, R3, R4, R5, and R6 are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.

S-[1-(2,3-diaminophenoxy)]-3'-(N-t-butylamino)propan-2'-ol - simplified asymmetric synthesis with CD and chiral HPLC analysis

S-[1-(2,3-diaminophenoxy)]-3'-(N-t-butylamino)propan-2'-ol is important as a precursor in the radiosynthesis of a 11C-labelled radioligand (S-[carbonyl-11C]CGP 12177) for the study of β-receptors in living man. The asymmetric synthes

Stereoselective synthesis of the (R)- and (S)-1-(2-amino-3-nitrophenoxy)-3-(tert-butylamino)-2-propanol from the enantiomeric glycidyl tosylates

The preparation of both enantiomers of 1-(2-amino-3-nitrophenoxy)-3-(tert-butylamino)-2-propanol from the enantiomeric glycidyl tosylates is described.