132178-17-7

Upstream product

• 614-20-0 3-oxo-3-phenylpropionic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 4636-16-2 iodoacetophenone 
• 98-86-2 acetophenone 
• 70-11-1 α-bromoacetophenone 
• 1669-49-4 3-(4-methoxyphenyl)-1-phenylpropan-1-one 
• 6969-02-4 [3-(4-methoxyphenyl)oxiran-2-yl]phenylmethanone 
• 27729-95-9 trans-4-methoxychalcone epoxide 
• 117954-06-0 1-methoxy-4-(2-phenylcyclopropyl)benzene 
• 959-33-1 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one 

Downstream Products

• 959-33-1 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one 

Relevant academic research and scientific papers

Aldol reactions of α-bromoalkyl phenyl ketones and aldehydes with tin(IV) iodide and tetrabutylammonium iodide

Aldol reactions of α-bromoacetophenone and aldehydes in dichloromethane produced the corresponding E-α,β-unsaturated ketones at 25 °C with one equimolar amount of tin(IV) iodide, one equimolar amount of tetrabutylammonium iodide and one equimolar amount of N,N- diisopropylethylamine, and produced the corresponding β-hydroxy ketones at -80 °C with one equimolar amount of tin(IV) iodide and two equimolar amounts of tetrabutylammonium iodide. Using one equimolar amount of tin(IV) iodide and two equimolar amounts of tetrabutylammonium iodide at -80 °C in dichloromethane, α-bromopropiophenone reacted with aldehydes to afford the corresponding syn-α-methyl-β-hydroxy ketones selectively. Georg Thieme Verlag Stuttgart.

Samarium(II) diiodide-mediated intermolecular aldol type reactions of phenacyl bromides with carbonyl compounds

Intermolecular aldol type reactions of phenacyl bromides with various carbonyl compounds mediated by samarium(II) diiodide afford β-hydroxy ketones in moderate to good yields.The addition of N,N,N',N'-tetramethylethylenediamine or diethylaluminium chlorid

Towards peptide isostere libraries: Aqueous aldol reactions on hydrophilic solid supports

Polar polyoxyethylene-polyoxypropylene (POEPOP) resin was derivatised with a 4-hydroxymethyl phenoxy linker and used as a solid support for lanthanide triflate catalysed Mukaiyama type solid phase aldol reactions. The conditions were optimised using resin bound 4-alkoxybenzaldehyde and it was shown that use of an aqueous solvent was crucial. Also, the reactions were performed with an N-terminal peptide aldehyde substrate in very high yields. POEPOP resins prepared with different monomer chain lengths and commercially available PEG-grafted NovaSyn TG resin were compared in the reactions.

Synthesis method of alpha or beta-substituted aromatic ketone

The invention discloses a synthesis method of alpha-or beta-substituted aromatic ketone. The method comprises the following steps: under the condition of inert gas, reacting alpha-oxo-aryl ethanone compounds, B2pin2, PDI-CoCl2 and MBHEt3 in an organic solvent at room temperature, then adding a compound 2, and continuously reacting to obtain a compound 3, wherein in the MBHEt3, M is an alkali metal; the compound 2 is selected from the group consisting of deuterated methanol, Selectfluoro, a TogniII reagent or R2CHO; R2 is an aromatic substituent or alkyl; the organic solvent is an aprotic organic solvent. According to the method, the alpha-oxo aryl ethanone is used as a raw material, a cheap and stable boron reagent and an efficient cobalt catalyst which is cheap and easy to obtain are used, an activating reagent MBHEt3 is added to generate an enol boron ether intermediate, then the enol boron ether intermediate and different electrophilic reagents are synthesized into alpha-or beta-substituted aromatic ketone, the reaction is carried out at normal temperature, and the operation is convenient.

All at once arrangement of both oxygen atoms of dioxygen into aliphatic C(sp3)-C(sp3) bonds for hydroxyketone difunctionalization

Both β- and γ- hydroxyketone structures are important units in biologically active molecules, synthetic drugs and fine chemicals. Although there are some routes available for their manufacture from pre-functionalized groups on one or two matrix molecule(s), the approaches to simply and simultaneously deposit two oxygen atoms from dioxygen into two specific C(sp3) positions of pure saturated hydrocarbons have rarely succeeded because they are involved in the targeted activation of three inert C-H σ bonds all at once. Here, we show that a TiO2-CH3CN photocatalytic suspension system enables the insertion of dioxygen into one C(sp3)-C(sp3) bond of strained cycloparaffin derivatives, by which difunctionalized hydroxyketone products are obtained in a one-pot reaction. With the cleavage event to release strain as the directional driving force, as-designed photocatalytic reaction systems show 21 examples of β-hydroxyketone products with 31%–76% isolated yields for three-membered ring derivatives and 5 examples of γ-hydroxyketone products with 30%–63% isolated yields for four-membered ring substrates. 18O isotopic labeling experiments using 18O2, Ti18O2 and intentionally added H218O, respectively, indicated that both oxygen atoms of hydroxyketone products were exclusively from dioxygen, suggesting a previously unknown H+/TiO2-e? catalyzed arrangement pathway of the hydroperoxide intermediate to convert dioxygen into hydroxyketone units. [Figure not available: see fulltext.]

Methods of preparing organic boron compound and beta-carbonyl compound by catalyzing copper ion loaded chitosan microspheres

The invention relates to methods of preparing an organic boron compound and a beta-carbonyl compound by catalyzing copper ion loaded chitosan microspheres. The preparation method of the organic boroncompound mainly comprises the following steps of A, addi

Method for preparing organoboron compound and beta-hydroxy compound by supported copper ion Y type molecular sieve catalyst

The invention relates to a method for preparing an organoboron compound and a beta-hydroxy compound by a supported copper ion Y type molecular sieve catalyst. The method for preparing the organoboroncompound mainly comprises the following steps: the step

Method for preparing organoboron compound under catalytic effect of chitosan immobilized copper and application

The invention discloses a method for preparing an organoboron compound under a catalytic effect of chitosan immobilized copper and an application. The method comprises the following steps: A) adding a chitosan immobilized copper catalyst and a ligand into a reaction tube and stirring; B) respectively continuously adding an initial raw material I and bisdiboron into a system in turn; C) stirring the whole reaction system and reacting under room temperature; D) after the reaction is ended, filtering the whole reaction system, washing with tetrahydrofuran, performing rotary evaporation and concentration on a filtrate, adopting a mixed solvent of ethyl acetate and petroleum ether at different ratios for performing column chromatography on the residues, separating and purifying, thereby acquiring a target product II. The silica gel is taken as a fixing phase for column chromatography. The invention also relates to the application of the prepared organoboron compound in compounding beta-hydroxy compound and anti-cancer drug molecules. The method is feasible; the operation is simple and convenient; the method is suitable for various substrates and can be used for successfully preparing the corresponding target compounds. The catalyst is low in dosage and is recyclable, is easily separated after the ending of the reaction, is free from metal residue and is suitable for large-scale production.

A green and recyclable chitosan supported catalyst for the borylation of α,β-unsaturated acceptors in water

We herein report a green and recyclable chitosan supported copper catalyst which is capable of catalyzing the borylation of α,β-unsaturated acceptors in water at room temperature. A broad substrate scope including chalcone derivatives, esters and nitriles have been explored. In all the cases, desired products were obtained in good to excellent yields. Remarkably, this chitosan supported catalyst could be recovered and reused for five times without any significant decrease of reactivity.

Visible light-promoted reductive transformations of various organic substances by using hydroxyaryl-substituted benzimidazolines and bases

Visible light promoted reduction reactions of organohalides, sulfonamides, organonitriles and epoxy ketones were performed using 1,3-dimethylbenzimidazolines possessing 2-hydroxynaphthyl or 2-hydroxyphenyl substituents (HOAr-DMBIH) as photo-reductants. Xe or Hg–Xe lamp through an appropriate glass-filter (λ>390 nm) and a household white light-emitting diode were used as light sources. In these reactions, reductive cleavages of carbon[sbnd]halogen, nitrogen[sbnd]sulfur, carbon[sbnd]carbon (nitrile) and carbon[sbnd]oxygen bonds take place. Bases exert significant effects on the progress of these reactions in a manner that depends on the nature of the substrate. Addition of 1,8-diazabicyclo[5.4.0]undec-7-ene as well as potassium t-butoxide significantly accelerates photo-reduction reactions of organohalides, sulfonamides and organonitriles while the decomposition of formed hydroxy ketones occurs in reactions of epoxy ketones. Single electron transfer from the photo-excited states of benzimidazolines (HOAr-DMBIH) or their deprotonated analogues (?OAr-DMBIH) to the substrates is proposed to initiate these reactions.