1321848-81-0Relevant articles and documents
Synthesis of chiral NADH analog based on proline template including thiourea and nicotinic acid moieties
Bagdziunas, Gintautas,Haukka, Matti,Butkus, Eugenijus
, p. 2517 - 2523 (2011/08/07)
Chiral reductase-mimicking organic molecule built on proline template incorporating a covalently bound NADH mimic via thiourea, and related reducing agent Hantzsch dihydropyridine, was designed. A synthetic path was developed involving interlinking of chiral proline derivatives with thiourea and subsequent coupling reaction with nicotinoyl chloride. The structure of target compound was studied by x-ray, indicating a double H bond with thiourea hydrogens and oxygen O1 of benzylcarbamate fragment. The reduction of benzil and imines was performed. Taylor & Francis Group, LLC.