13219-76-6Relevant articles and documents
Investigations regarding the utility of prodigiosenes to treat leukemia
Smithen, Deborah A.,Forrester, A. Michael,Corkery, Dale P.,Dellaire, Graham,Colpitts, Julie,McFarland, Sherri A.,Berman, Jason N.,Thompson, Alison
, p. 62 - 68 (2013/02/23)
Prodigiosenes, possessing a 4-methoxypyrrolyldipyrrin skeleton, are known for their anti-cancer activity. Structural modification of the C-ring resulted in a series of prodigiosenes that displayed promising activity against leukemia cell lines during in v
Novel inhibitor for fibroblast growth factor receptor tyrosine kinase
Kammasud, Naparat,Boonyarat, Chantana,Tsunoda, Satoshi,Sakurai, Hiroaki,Saiki, Ikuo,Grierson, David S.,Vajragupta, Opa
, p. 4812 - 4818 (2008/02/12)
NP603, the 6-dimethoxy phenyl indolin-2-one, was designed as FGF receptor 1 inhibitor by computational study. NP603 was synthesized and found to be more active against endothelial proliferation of HUVEC after the rhFGF-2 stimulation than SU6668 with minim
Indolinone compounds as kinase inhibitors
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Page/Page column 96, (2010/11/30)
The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to methods of modulating the function of protein kinases using indolinone compounds of the invention and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.