13219-97-1

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(2-methyl-5-phenyl-1H-pyrrol-3-yl)ethanone is used as a key building block in the pharmaceutical industry for the synthesis of various drugs. Its unique structure allows for the creation of a wide range of medicinal compounds with diverse therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, 1-(2-methyl-5-phenyl-1H-pyrrol-3-yl)ethanone serves as an essential component in the development of new pesticides and other agricultural chemicals. Its incorporation into these products can enhance their effectiveness and target specific pests or diseases.
Used in Organic Synthesis:
1-(2-methyl-5-phenyl-1H-pyrrol-3-yl)ethanone is utilized as an intermediate in organic synthesis, allowing for the creation of a variety of organic compounds with different properties and applications. Its versatility makes it a valuable asset in the development of new materials and chemicals.
Used in Medicinal Chemistry Research:
Due to its potential biological activities, including antifungal and antibacterial properties, 1-(2-methyl-5-phenyl-1H-pyrrol-3-yl)ethanone is employed in medicinal chemistry research. Scientists use 1-(2-methyl-5-phenyl-1H-pyrrol-3-yl)ethanone to explore new avenues for drug discovery and to develop novel therapeutic agents.

Upstream product

• 22114-27-8 2,4,6-trimethylpyrimidine 
• 70-11-1 α-bromoacetophenone 
• 100393-32-6 1-(1-hydroxy-2-methyl-5-phenyl-pyrrol-3-yl)-ethanone 
• 52313-43-6 3-acetyl-1-phenyl-pentane-1,4-dione 
• 631-61-8 ammonium acetate 
• 7664-41-7 ammonia 
• 16722-99-9 β-azidostyrene 
• 123-54-6 acetylacetone 
• 1118-66-7 4-amino-3-penten-2-one 
• 1074-12-0 phenylglyoxal hydrate 
• 536-74-3 phenylacetylene 
• 16717-64-9 1-azidostyrene 
• 56464-39-2 4-acetyl-3-amino-5-methyl-2-phenyl-pyrrole 

Downstream Products

• 127394-90-5 4-acetyl-1,5-dimethyl-3-nitro-2-phenylpyrrole 
• 56464-19-8 4-amino-1,2-dimethyl-5-phenylpyrrol-3-yl-etanone 
• 130870-91-6 1-(4-Bromo-2-methyl-5-phenyl-1H-pyrrol-3-yl)-ethanone 
• 127394-88-1 4-acetyl-5-methyl-3-nitro-2-phenylpyrrole 

Relevant academic research and scientific papers

I2-DMSO promoted metal free oxidative cyclization for the synthesis of substituted Indoles and pyrroles

A series of di substituted indole and tri substituted pyrrole derivatives were synthesized efficiently by using I2/K2CO3 in DMSO. The novel synthesis method offers the advantage of mild reaction conditions, operational simplicity, higher yields. The method is functional group tolerant and provides quick access to medicinally significant compounds in moderate to high yields.

Green multicomponent reaction for synthesis of trisubstituted pyrroles in ionic liquid [bmim]BF4

2,4,5-Trisubstituted pyrrole derivatives were efficiently synthesized by one-pot condensation of 1,3-diones, α-bromoacetophenones, and ammonium acetate in ionic liquid [bmim]BF4. The new synthetic method offers multisubstituted pyrroles with th

Microwave-assisted facile synthesis of trisubstituted pyrrole derivatives

We report efficient synthesis of pyrrole derivatives by use of microwave irradiation. Quantitative yields were obtained in short reaction times. Low yields of product were obtained from alicyclic amino unsaturated ketone derivatives; higher yields were ob

Infrared heat aided solid state synthesis of pyrroles from 1,4-diketones and ammonium acetate

A facile amination of 1,4-diketones with ammonium acetate has been achieved by mechanochemical grinding assisted by infrared irradiation in the presence of silica gel. The wastes are reduced and the energy resources saved..

Multicomponent approach towards the synthesis of substituted pyrroles under supramolecular catalysis using β-cyclodextrin as a catalyst in water under neutral conditions

Synthesis of substituted pyrroles in H2O by using β-cyclodextrin as a supramolecular catalyst is described. This reaction has several advantages over existing methods and provides substituted pyrroles in good-to-excellent yields (79-89%). The s

Mn(III)-catalyzed synthesis of pyrroles from vinyl azides and 1,3-dicarbonyl compounds

(Chemical Equation Presented) Polysubstituted N-H pyrroles with a wide variety of substituents were prepared from vinyl azides and 1,3-dicarbonyl compounds by using Mn(III) complexes as catalysts.

Synthesis of polysubstituted N-H pyrroles from vinyl azides and 1,3-dicarbonyl compounds

(Chemical Equation Presented) Two synthetic methods for tetra- and trisubstituted N-H pyrroles are presented: (i) the thermal pyrrole formation by the reaction of vinyl azides with 1,3-dicarbonyl compounds via the 1,2-addition of 1,3-dicarbonyl compounds to 2H-azirine intermediates generated in situ from vinyl azides; (ii) the Cu(II)-catalyzed synthesis of pyrroles from α-ethoxycarbonyl vinyl azides and ethyl acetoacetate through the 1,4-addition reaction of the acetoacetate to the vinyl azides. By applying these two methods, regioisomeric pyrroles can be prepared selectively starting from the same vinyl azides.

Oxidative Halogenation of Substituted Pyrroles with Cu(II). Part I. Bromination of some 3-Acetylpyrroles

3-Acetylpyrroles are brominated with copper(II) bromide.The reaction afforded almost quantitatively only nuclear monobromination.Evidence for the structures of final compounds was by mass spectrometry, 1H-nuclear magnetic resonance, ir, and elemental analysis.

POLYCONDENSED NITROGEN HETEROCYCLES. PART XIV. REACTIVITY OF 3-DIAZOPYRROLES: PYRROLOPYRIDAZINE

3-Diazopyrroles 2a,b were prepared in excellent yields by diazotization of the corresponding amines 1a,b.Compounds 2a,b, by acid catalyzed intramolecular coupling reaction led to the new ring system pyrrolopyridazine 3a,b.